Increased prevalence of autoantibodies to Ku antigen in African American versus white patients with systemic lupus erythematosus
Objective To investigate whether the widely varying estimates of the prevalence of anti‐Ku autoantibodies are explained by racial/ethnic differences. Methods Consecutive African American or white patients who met the 1982 criteria for systemic lupus erythematosus (SLE) and who were evaluated over 10...
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| Veröffentlicht in: | Arthritis and rheumatism 2001-10, Vol.44 (10), p.2367-2370 |
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| creator | Wang, Jingsong Satoh, Minoru Kabir, Fathima Shaw, Melody Domingo, Mary Ann Mansoor, Rizwan Behney, Krista M. Dong, Xingwen Lahita, Robert G. Richards, Hanno B. Reeves, Westley H. |
| description | Objective
To investigate whether the widely varying estimates of the prevalence of anti‐Ku autoantibodies are explained by racial/ethnic differences.
Methods
Consecutive African American or white patients who met the 1982 criteria for systemic lupus erythematosus (SLE) and who were evaluated over 10 years in North Carolina, Florida, and New York were tested by immunoprecipitation of K562 cell extract for anti‐Ku as well as anti–nuclear RNP (nRNP)/Sm, anti‐Ro/SSA, and anti‐La/SSB autoantibodies.
Results
Anti‐Ku autoantibodies were detected in sera from 18 of 155 African American patients with SLE (12%) versus 0 of 126 white patients (P < 0.0001, by Fisher's exact test). Anti‐nRNP (63% versus 16%; P < 0.0001) and anti‐Sm (23% versus 7%; P < 0.0004) autoantibodies were also more common in the African American subset. The 2 groups had comparable frequencies of anti‐Ro/SSA and anti‐La/SSB autoantibodies.
Conclusion
Anti‐Ku antibodies are common in African American patients with SLE but rare in whites, probably explaining the different estimates of their prevalence. In African Americans, the frequency is comparable with that of anti‐La/SSB. Along with anti‐Ku, anti‐nRNP and anti‐Sm autoantibodies are also overrepresented in African Americans, suggesting that a group of specificities is characteristically associated with SLE in African Americans. |
| doi_str_mv | 10.1002/1529-0131(200110)44:10<2367::AID-ART400>3.0.CO;2-I |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72215343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72215343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4650-873948e7b8451a6e1412a6edea26027e7f65df35d5e7b44c6012a9d2ed7563643</originalsourceid><addsrcrecordid>eNqVkU2P0zAQhi0EYsvCX0C-gOCQ4u80BSFV5StipUqr5Wy5zoQa5Qvb2VVv_HQcJdq9cOE0nplnXo_mRWhLyZoSwt5RyYqMUE7fMEIoJW-FSL0PjKt8u92Vn7Ld9Y0g5CNfk_X-8J5l5SO0uh96jFaEEJFxWdAL9CyEXyllXPKn6IJSpWSRb1boT9lZDyZAhQcPt6aBzgLua2zG2JsuumNfOQg49vj7iKfCT-iw6_Cu9s6aFFuYH7fgwxjw3clFwIOJDrqYUhdPOJxDhNZZ3IxDQsCf4wlaE_s08Bw9qU0T4MUSL9GPL59v9t-yq8PXcr-7yqxQkmSbnBdiA_lxIyQ1CqigLIUKDFOE5ZDXSlY1l5VMjBBWkdQvKgZVLhVXgl-i17Pu4PvfI4SoWxcsNI3poB-DzhmjkguewOsZtL4PwUOtB-9a48-aEj35oqcT6-nEevZFCzH1Jl-0Tr7o2RfNNdH7g2a6TKIvl9_HYwvVg-RiRAJeLYAJ1jS1N5114YETlAhFcn5_njvXwPm_VvvnZkuF_wUED7T2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72215343</pqid></control><display><type>article</type><title>Increased prevalence of autoantibodies to Ku antigen in African American versus white patients with systemic lupus erythematosus</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Wang, Jingsong ; Satoh, Minoru ; Kabir, Fathima ; Shaw, Melody ; Domingo, Mary Ann ; Mansoor, Rizwan ; Behney, Krista M. ; Dong, Xingwen ; Lahita, Robert G. ; Richards, Hanno B. ; Reeves, Westley H.</creator><creatorcontrib>Wang, Jingsong ; Satoh, Minoru ; Kabir, Fathima ; Shaw, Melody ; Domingo, Mary Ann ; Mansoor, Rizwan ; Behney, Krista M. ; Dong, Xingwen ; Lahita, Robert G. ; Richards, Hanno B. ; Reeves, Westley H.</creatorcontrib><description>Objective
To investigate whether the widely varying estimates of the prevalence of anti‐Ku autoantibodies are explained by racial/ethnic differences.
Methods
Consecutive African American or white patients who met the 1982 criteria for systemic lupus erythematosus (SLE) and who were evaluated over 10 years in North Carolina, Florida, and New York were tested by immunoprecipitation of K562 cell extract for anti‐Ku as well as anti–nuclear RNP (nRNP)/Sm, anti‐Ro/SSA, and anti‐La/SSB autoantibodies.
Results
Anti‐Ku autoantibodies were detected in sera from 18 of 155 African American patients with SLE (12%) versus 0 of 126 white patients (P < 0.0001, by Fisher's exact test). Anti‐nRNP (63% versus 16%; P < 0.0001) and anti‐Sm (23% versus 7%; P < 0.0004) autoantibodies were also more common in the African American subset. The 2 groups had comparable frequencies of anti‐Ro/SSA and anti‐La/SSB autoantibodies.
Conclusion
Anti‐Ku antibodies are common in African American patients with SLE but rare in whites, probably explaining the different estimates of their prevalence. In African Americans, the frequency is comparable with that of anti‐La/SSB. Along with anti‐Ku, anti‐nRNP and anti‐Sm autoantibodies are also overrepresented in African Americans, suggesting that a group of specificities is characteristically associated with SLE in African Americans.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/1529-0131(200110)44:10<2367::AID-ART400>3.0.CO;2-I</identifier><identifier>PMID: 11665978</identifier><identifier>CODEN: ARHEAW</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibody Specificity ; Antigens, Nuclear ; Autoantibodies - immunology ; Biological and medical sciences ; Black or African American ; Black People ; DNA Helicases ; DNA-Binding Proteins - immunology ; Female ; Humans ; Ku Autoantigen ; Lupus Erythematosus, Systemic - ethnology ; Lupus Erythematosus, Systemic - immunology ; Male ; Medical sciences ; Middle Aged ; Nuclear Proteins - immunology ; Prevalence ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; White People</subject><ispartof>Arthritis and rheumatism, 2001-10, Vol.44 (10), p.2367-2370</ispartof><rights>Copyright © 2001 by the American College of Rheumatology</rights><rights>2002 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4650-873948e7b8451a6e1412a6edea26027e7f65df35d5e7b44c6012a9d2ed7563643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1529-0131%28200110%2944%3A10%3C2367%3A%3AAID-ART400%3E3.0.CO%3B2-I$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1529-0131%28200110%2944%3A10%3C2367%3A%3AAID-ART400%3E3.0.CO%3B2-I$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14104607$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11665978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jingsong</creatorcontrib><creatorcontrib>Satoh, Minoru</creatorcontrib><creatorcontrib>Kabir, Fathima</creatorcontrib><creatorcontrib>Shaw, Melody</creatorcontrib><creatorcontrib>Domingo, Mary Ann</creatorcontrib><creatorcontrib>Mansoor, Rizwan</creatorcontrib><creatorcontrib>Behney, Krista M.</creatorcontrib><creatorcontrib>Dong, Xingwen</creatorcontrib><creatorcontrib>Lahita, Robert G.</creatorcontrib><creatorcontrib>Richards, Hanno B.</creatorcontrib><creatorcontrib>Reeves, Westley H.</creatorcontrib><title>Increased prevalence of autoantibodies to Ku antigen in African American versus white patients with systemic lupus erythematosus</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective
To investigate whether the widely varying estimates of the prevalence of anti‐Ku autoantibodies are explained by racial/ethnic differences.
Methods
Consecutive African American or white patients who met the 1982 criteria for systemic lupus erythematosus (SLE) and who were evaluated over 10 years in North Carolina, Florida, and New York were tested by immunoprecipitation of K562 cell extract for anti‐Ku as well as anti–nuclear RNP (nRNP)/Sm, anti‐Ro/SSA, and anti‐La/SSB autoantibodies.
Results
Anti‐Ku autoantibodies were detected in sera from 18 of 155 African American patients with SLE (12%) versus 0 of 126 white patients (P < 0.0001, by Fisher's exact test). Anti‐nRNP (63% versus 16%; P < 0.0001) and anti‐Sm (23% versus 7%; P < 0.0004) autoantibodies were also more common in the African American subset. The 2 groups had comparable frequencies of anti‐Ro/SSA and anti‐La/SSB autoantibodies.
Conclusion
Anti‐Ku antibodies are common in African American patients with SLE but rare in whites, probably explaining the different estimates of their prevalence. In African Americans, the frequency is comparable with that of anti‐La/SSB. Along with anti‐Ku, anti‐nRNP and anti‐Sm autoantibodies are also overrepresented in African Americans, suggesting that a group of specificities is characteristically associated with SLE in African Americans.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibody Specificity</subject><subject>Antigens, Nuclear</subject><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>DNA Helicases</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Ku Autoantigen</subject><subject>Lupus Erythematosus, Systemic - ethnology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nuclear Proteins - immunology</subject><subject>Prevalence</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>White People</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU2P0zAQhi0EYsvCX0C-gOCQ4u80BSFV5StipUqr5Wy5zoQa5Qvb2VVv_HQcJdq9cOE0nplnXo_mRWhLyZoSwt5RyYqMUE7fMEIoJW-FSL0PjKt8u92Vn7Ld9Y0g5CNfk_X-8J5l5SO0uh96jFaEEJFxWdAL9CyEXyllXPKn6IJSpWSRb1boT9lZDyZAhQcPt6aBzgLua2zG2JsuumNfOQg49vj7iKfCT-iw6_Cu9s6aFFuYH7fgwxjw3clFwIOJDrqYUhdPOJxDhNZZ3IxDQsCf4wlaE_s08Bw9qU0T4MUSL9GPL59v9t-yq8PXcr-7yqxQkmSbnBdiA_lxIyQ1CqigLIUKDFOE5ZDXSlY1l5VMjBBWkdQvKgZVLhVXgl-i17Pu4PvfI4SoWxcsNI3poB-DzhmjkguewOsZtL4PwUOtB-9a48-aEj35oqcT6-nEevZFCzH1Jl-0Tr7o2RfNNdH7g2a6TKIvl9_HYwvVg-RiRAJeLYAJ1jS1N5114YETlAhFcn5_njvXwPm_VvvnZkuF_wUED7T2</recordid><startdate>200110</startdate><enddate>200110</enddate><creator>Wang, Jingsong</creator><creator>Satoh, Minoru</creator><creator>Kabir, Fathima</creator><creator>Shaw, Melody</creator><creator>Domingo, Mary Ann</creator><creator>Mansoor, Rizwan</creator><creator>Behney, Krista M.</creator><creator>Dong, Xingwen</creator><creator>Lahita, Robert G.</creator><creator>Richards, Hanno B.</creator><creator>Reeves, Westley H.</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200110</creationdate><title>Increased prevalence of autoantibodies to Ku antigen in African American versus white patients with systemic lupus erythematosus</title><author>Wang, Jingsong ; Satoh, Minoru ; Kabir, Fathima ; Shaw, Melody ; Domingo, Mary Ann ; Mansoor, Rizwan ; Behney, Krista M. ; Dong, Xingwen ; Lahita, Robert G. ; Richards, Hanno B. ; Reeves, Westley H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4650-873948e7b8451a6e1412a6edea26027e7f65df35d5e7b44c6012a9d2ed7563643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibody Specificity</topic><topic>Antigens, Nuclear</topic><topic>Autoantibodies - immunology</topic><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>DNA Helicases</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Ku Autoantigen</topic><topic>Lupus Erythematosus, Systemic - ethnology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nuclear Proteins - immunology</topic><topic>Prevalence</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>White People</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jingsong</creatorcontrib><creatorcontrib>Satoh, Minoru</creatorcontrib><creatorcontrib>Kabir, Fathima</creatorcontrib><creatorcontrib>Shaw, Melody</creatorcontrib><creatorcontrib>Domingo, Mary Ann</creatorcontrib><creatorcontrib>Mansoor, Rizwan</creatorcontrib><creatorcontrib>Behney, Krista M.</creatorcontrib><creatorcontrib>Dong, Xingwen</creatorcontrib><creatorcontrib>Lahita, Robert G.</creatorcontrib><creatorcontrib>Richards, Hanno B.</creatorcontrib><creatorcontrib>Reeves, Westley H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jingsong</au><au>Satoh, Minoru</au><au>Kabir, Fathima</au><au>Shaw, Melody</au><au>Domingo, Mary Ann</au><au>Mansoor, Rizwan</au><au>Behney, Krista M.</au><au>Dong, Xingwen</au><au>Lahita, Robert G.</au><au>Richards, Hanno B.</au><au>Reeves, Westley H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased prevalence of autoantibodies to Ku antigen in African American versus white patients with systemic lupus erythematosus</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>2001-10</date><risdate>2001</risdate><volume>44</volume><issue>10</issue><spage>2367</spage><epage>2370</epage><pages>2367-2370</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><coden>ARHEAW</coden><abstract>Objective
To investigate whether the widely varying estimates of the prevalence of anti‐Ku autoantibodies are explained by racial/ethnic differences.
Methods
Consecutive African American or white patients who met the 1982 criteria for systemic lupus erythematosus (SLE) and who were evaluated over 10 years in North Carolina, Florida, and New York were tested by immunoprecipitation of K562 cell extract for anti‐Ku as well as anti–nuclear RNP (nRNP)/Sm, anti‐Ro/SSA, and anti‐La/SSB autoantibodies.
Results
Anti‐Ku autoantibodies were detected in sera from 18 of 155 African American patients with SLE (12%) versus 0 of 126 white patients (P < 0.0001, by Fisher's exact test). Anti‐nRNP (63% versus 16%; P < 0.0001) and anti‐Sm (23% versus 7%; P < 0.0004) autoantibodies were also more common in the African American subset. The 2 groups had comparable frequencies of anti‐Ro/SSA and anti‐La/SSB autoantibodies.
Conclusion
Anti‐Ku antibodies are common in African American patients with SLE but rare in whites, probably explaining the different estimates of their prevalence. In African Americans, the frequency is comparable with that of anti‐La/SSB. Along with anti‐Ku, anti‐nRNP and anti‐Sm autoantibodies are also overrepresented in African Americans, suggesting that a group of specificities is characteristically associated with SLE in African Americans.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11665978</pmid><doi>10.1002/1529-0131(200110)44:10<2367::AID-ART400>3.0.CO;2-I</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antibody Specificity Antigens, Nuclear Autoantibodies - immunology Biological and medical sciences Black or African American Black People DNA Helicases DNA-Binding Proteins - immunology Female Humans Ku Autoantigen Lupus Erythematosus, Systemic - ethnology Lupus Erythematosus, Systemic - immunology Male Medical sciences Middle Aged Nuclear Proteins - immunology Prevalence Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis White People |
| title | Increased prevalence of autoantibodies to Ku antigen in African American versus white patients with systemic lupus erythematosus |
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