Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart

Myotonic dystrophy (DM) is a multisystemic disorder caused by an inherited CTG repeat expansion which affects three genes encoding the DM protein kinase (DMPK), a homeobox protein Six5 and a protein containing WD repeats. Using a panel of 16 monoclonal antibodies against several different DMPK epito...

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Veröffentlicht in:	Human molecular genetics 2000-09, Vol.9 (14), p.2167-2173
Hauptverfasser:	LAM, L. T, PHAM, Y. C. N, NGUYEN THI MAN, MORRIS, G. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - chemistry Base Sequence Biological and medical sciences Blotting, Western Brain - metabolism Catalytic Domain Diseases of striated muscles. Neuromuscular diseases DMPK protein DNA, Complementary - metabolism Electrophoresis, Polyacrylamide Gel Epitopes Gene Library Humans Medical sciences Molecular Sequence Data Muscle, Skeletal - metabolism Muscle, Smooth - metabolism Muscles - metabolism Myocardium - metabolism myotonic dystrophy Myotonic Dystrophy - genetics Myotonic Dystrophy - metabolism Myotonin-Protein Kinase Neurology Peptide Library Protein Structure, Tertiary Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Sequence Homology, Amino Acid Tissue Distribution Trinucleotide Repeat Expansion
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