Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders
Background: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case–control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its rel...
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| Veröffentlicht in: | Biological psychiatry (1969) 2000-08, Vol.48 (4), p.319-322 |
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| creator | Bellivier, Frank Szöke, Andreı̈ Henry, Chantal Lacoste, Jérome Bottos, Corinne Nosten-Bertrand, Marika Hardy, Patrick Rouillon, Frederic Launay, Jean-Marie Laplanche, Jean-Louis Leboyer, Marion |
| description | Background: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case–control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior.
Methods: A functional polymorphism of the 5-HTT gene (a 44–base pair insertion/deletion in the 5-HTT–linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt.
Results: No association was found between the “s” allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects.
Conclusions: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings. |
| doi_str_mv | 10.1016/S0006-3223(00)00891-X |
| format | Article |
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Methods: A functional polymorphism of the 5-HTT gene (a 44–base pair insertion/deletion in the 5-HTT–linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt.
Results: No association was found between the “s” allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects.
Conclusions: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(00)00891-X</identifier><identifier>PMID: 10960164</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; affective disorder ; Alleles ; Biological and medical sciences ; Bipolar Disorder - genetics ; candidate symptoms ; Carrier Proteins - genetics ; Depression ; Depressive Disorder, Major - genetics ; Female ; Gene Expression ; Humans ; Male ; Medical sciences ; Membrane Glycoproteins - genetics ; Membrane Transport Proteins ; Mood disorders ; Mood Disorders - genetics ; Nerve Tissue Proteins ; Polymorphism, Genetic ; Promoter Regions, Genetic - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Serotonin - genetics ; Serotonin Plasma Membrane Transport Proteins ; Serotonin transporter gene ; suicidal behavior ; Suicide - psychology ; Violence - psychology</subject><ispartof>Biological psychiatry (1969), 2000-08, Vol.48 (4), p.319-322</ispartof><rights>2000 Society of Biological Psychiatry</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-5b76748cb2b1394de38828d13635200a3249e6c7102f642052dd181445c457623</citedby><cites>FETCH-LOGICAL-c503t-5b76748cb2b1394de38828d13635200a3249e6c7102f642052dd181445c457623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(00)00891-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1491391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10960164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellivier, Frank</creatorcontrib><creatorcontrib>Szöke, Andreı̈</creatorcontrib><creatorcontrib>Henry, Chantal</creatorcontrib><creatorcontrib>Lacoste, Jérome</creatorcontrib><creatorcontrib>Bottos, Corinne</creatorcontrib><creatorcontrib>Nosten-Bertrand, Marika</creatorcontrib><creatorcontrib>Hardy, Patrick</creatorcontrib><creatorcontrib>Rouillon, Frederic</creatorcontrib><creatorcontrib>Launay, Jean-Marie</creatorcontrib><creatorcontrib>Laplanche, Jean-Louis</creatorcontrib><creatorcontrib>Leboyer, Marion</creatorcontrib><title>Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case–control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior.
Methods: A functional polymorphism of the 5-HTT gene (a 44–base pair insertion/deletion in the 5-HTT–linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt.
Results: No association was found between the “s” allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects.
Conclusions: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>affective disorder</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - genetics</subject><subject>candidate symptoms</subject><subject>Carrier Proteins - genetics</subject><subject>Depression</subject><subject>Depressive Disorder, Major - genetics</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Transport Proteins</subject><subject>Mood disorders</subject><subject>Mood Disorders - genetics</subject><subject>Nerve Tissue Proteins</subject><subject>Polymorphism, Genetic</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Serotonin - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins</subject><subject>Serotonin transporter gene</subject><subject>suicidal behavior</subject><subject>Suicide - psychology</subject><subject>Violence - psychology</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7uzqT1ByENFDa-Wjv04ii6vCgoIKewvppMaNdCdtKrOy_97MzqDePIUKz_tW8jD2RMArAaJ7_QUAukZJqV4AvAQYRtFc3WMbMfSqkRrkfbb5g5ywU6IfdeylFA_ZiYCxqyV6w8rnRBSmGbklSi7YElLkE5ZfiJET5lRSDJGXbCOtKRfM_DtG5Guab5eU1-tAC7fR85uQZoyF0y644O1cS65tvcy8xpeUPPeBUvaY6RF7sLUz4ePjeca-Xbz7ev6hufz0_uP528vGtaBK00591-vBTXISatQe1TDIwQvVqVYCWCX1iJ3rBchtpyW00nsxCK1bp9u-k-qMPT_0rjn93CEVswRyOM82YtqR2dvQPfQVbA-gy1VHxq1Zc1hsvjUCzF63udNt9i4NgLnTba5q7ulxwW5a0P-TOvitwLMjYMnZeVstukB_OT3Wn4mKvTlgWG3cBMyGXMDo0IeMrhifwn9e8htt0J0o</recordid><startdate>20000815</startdate><enddate>20000815</enddate><creator>Bellivier, Frank</creator><creator>Szöke, Andreı̈</creator><creator>Henry, Chantal</creator><creator>Lacoste, Jérome</creator><creator>Bottos, Corinne</creator><creator>Nosten-Bertrand, Marika</creator><creator>Hardy, Patrick</creator><creator>Rouillon, Frederic</creator><creator>Launay, Jean-Marie</creator><creator>Laplanche, Jean-Louis</creator><creator>Leboyer, Marion</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000815</creationdate><title>Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders</title><author>Bellivier, Frank ; Szöke, Andreı̈ ; Henry, Chantal ; Lacoste, Jérome ; Bottos, Corinne ; Nosten-Bertrand, Marika ; Hardy, Patrick ; Rouillon, Frederic ; Launay, Jean-Marie ; Laplanche, Jean-Louis ; Leboyer, Marion</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-5b76748cb2b1394de38828d13635200a3249e6c7102f642052dd181445c457623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>affective disorder</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - genetics</topic><topic>candidate symptoms</topic><topic>Carrier Proteins - genetics</topic><topic>Depression</topic><topic>Depressive Disorder, Major - genetics</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Transport Proteins</topic><topic>Mood disorders</topic><topic>Mood Disorders - genetics</topic><topic>Nerve Tissue Proteins</topic><topic>Polymorphism, Genetic</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Serotonin - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins</topic><topic>Serotonin transporter gene</topic><topic>suicidal behavior</topic><topic>Suicide - psychology</topic><topic>Violence - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellivier, Frank</creatorcontrib><creatorcontrib>Szöke, Andreı̈</creatorcontrib><creatorcontrib>Henry, Chantal</creatorcontrib><creatorcontrib>Lacoste, Jérome</creatorcontrib><creatorcontrib>Bottos, Corinne</creatorcontrib><creatorcontrib>Nosten-Bertrand, Marika</creatorcontrib><creatorcontrib>Hardy, Patrick</creatorcontrib><creatorcontrib>Rouillon, Frederic</creatorcontrib><creatorcontrib>Launay, Jean-Marie</creatorcontrib><creatorcontrib>Laplanche, Jean-Louis</creatorcontrib><creatorcontrib>Leboyer, Marion</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellivier, Frank</au><au>Szöke, Andreı̈</au><au>Henry, Chantal</au><au>Lacoste, Jérome</au><au>Bottos, Corinne</au><au>Nosten-Bertrand, Marika</au><au>Hardy, Patrick</au><au>Rouillon, Frederic</au><au>Launay, Jean-Marie</au><au>Laplanche, Jean-Louis</au><au>Leboyer, Marion</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2000-08-15</date><risdate>2000</risdate><volume>48</volume><issue>4</issue><spage>319</spage><epage>322</epage><pages>319-322</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case–control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior.
Methods: A functional polymorphism of the 5-HTT gene (a 44–base pair insertion/deletion in the 5-HTT–linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt.
Results: No association was found between the “s” allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects.
Conclusions: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10960164</pmid><doi>10.1016/S0006-3223(00)00891-X</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological psychiatry (1969), 2000-08, Vol.48 (4), p.319-322 |
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| subjects | Adult Adult and adolescent clinical studies affective disorder Alleles Biological and medical sciences Bipolar Disorder - genetics candidate symptoms Carrier Proteins - genetics Depression Depressive Disorder, Major - genetics Female Gene Expression Humans Male Medical sciences Membrane Glycoproteins - genetics Membrane Transport Proteins Mood disorders Mood Disorders - genetics Nerve Tissue Proteins Polymorphism, Genetic Promoter Regions, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin - genetics Serotonin Plasma Membrane Transport Proteins Serotonin transporter gene suicidal behavior Suicide - psychology Violence - psychology |
| title | Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders |
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