Apoptosis of NG108-15 Cells Induced by Buprenorphine Hydrochloride Occurs via the Caspase-3 Pathway

Apoptosis of NG108-15 neuroblastoma×glioma hydrid cells (NG108-15 cells) is induced by a morphine alkaloid derivative, buprenorphine hydrochloride (Bph). In a previous report, we used various apotosis inhibitors to identify the "death pathway", and found that caspase inhibitors Ac-YVAD-CHO...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/08/01, Vol.23(8), pp.930-935
Hauptverfasser:	KUGAWA, Fumihiko, UENO, Akemichi, AOKI, Masatada
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death apoptosis Apoptosis - drug effects Biological and medical sciences Buprenorphine - pharmacology buprenorphine hydrochloride Caspase 3 Caspases - metabolism Cell physiology Drug toxicity and drugs side effects treatment Fundamental and applied biological sciences. Psychology Humans Hybrid Cells Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Molecular and cellular biology NG108-15 Pharmacology. Drug treatments Protein Kinases - metabolism TPCK (N-tosyl-L-phenylalanyl chloromethyl ketone) Tumor Cells, Cultured
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