Effect of Inhibitor of Tumor Necrosis Factor-Alpha on Experimental Otitis Media with Effusion
Tumor necrosis factor (TNF)-α is important in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of TNF-α antagonist on the outcome of lipopolysaccharide (LPS)-induced OME in rats. Otitis media was induced by injecting Pseudomonas aeruginosa L...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2001-10, Vol.110 (10), p.917-921 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Jeun, Eun-Ju Park, Yong-Soo Yeo, Sang W. Choi, Young-Chul Jung, Timothy T. K. |
| description | Tumor necrosis factor (TNF)-α is important in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of TNF-α antagonist on the outcome of lipopolysaccharide (LPS)-induced OME in rats. Otitis media was induced by injecting Pseudomonas aeruginosa LPS transtympanically. Another (combination) group was pretreated with TNF-α antagonist, soluble TNF receptor type I (sTNF RI), before transtympanic injection of LPS. Saline and phosphate-buffered saline solutions were used as controls. Twelve hours after the transtympanic injection, otoscopic examination and aspiration of middle ear effusion (MEE) were done. The temporal bones in each group were examined histopathologically, and the vascular permeability of the middle ear mucosa was measured by the Evans blue vital dye technique. In the LPS and combination groups, MEE developed in 90% and 0% of ears, respectively. The combination group showed less inflammation, less mucosal thickening, and significantly decreased vascular permeability as compared to the LPS group. Transtympanic administration of sTNF RI appears to suppress the development of LPS-induced OME. This study suggests that TNF-α antagonist, along with antibiotics, may have an adjunctive role in the future treatment of MEE. |
| doi_str_mv | 10.1177/000348940111001005 |
| format | Article |
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K.</creator><creatorcontrib>Jeun, Eun-Ju ; Park, Yong-Soo ; Yeo, Sang W. ; Choi, Young-Chul ; Jung, Timothy T. K.</creatorcontrib><description>Tumor necrosis factor (TNF)-α is important in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of TNF-α antagonist on the outcome of lipopolysaccharide (LPS)-induced OME in rats. Otitis media was induced by injecting Pseudomonas aeruginosa LPS transtympanically. Another (combination) group was pretreated with TNF-α antagonist, soluble TNF receptor type I (sTNF RI), before transtympanic injection of LPS. Saline and phosphate-buffered saline solutions were used as controls. Twelve hours after the transtympanic injection, otoscopic examination and aspiration of middle ear effusion (MEE) were done. The temporal bones in each group were examined histopathologically, and the vascular permeability of the middle ear mucosa was measured by the Evans blue vital dye technique. In the LPS and combination groups, MEE developed in 90% and 0% of ears, respectively. The combination group showed less inflammation, less mucosal thickening, and significantly decreased vascular permeability as compared to the LPS group. Transtympanic administration of sTNF RI appears to suppress the development of LPS-induced OME. This study suggests that TNF-α antagonist, along with antibiotics, may have an adjunctive role in the future treatment of MEE.</description><identifier>ISSN: 0003-4894</identifier><identifier>EISSN: 1943-572X</identifier><identifier>DOI: 10.1177/000348940111001005</identifier><identifier>PMID: 11642423</identifier><identifier>CODEN: AORHA2</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Ear, Middle - blood supply ; Ent. Stomatology ; Lipopolysaccharides - pharmacology ; Medical sciences ; Mucous Membrane - blood supply ; Non tumoral diseases ; Otitis Media with Effusion - etiology ; Otorhinolaryngology. Stomatology ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Receptors, Tumor Necrosis Factor - physiology ; Temporal Bone - pathology ; Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><ispartof>Annals of otology, rhinology & laryngology, 2001-10, Vol.110 (10), p.917-921</ispartof><rights>2001 SAGE Publications</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Annals Publishing Company Oct 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-c0bbc4320bc12f4844f71211ad98af7f788b4dc5b7bcc3e498f76becbc3e9ac43</citedby><cites>FETCH-LOGICAL-c396t-c0bbc4320bc12f4844f71211ad98af7f788b4dc5b7bcc3e498f76becbc3e9ac43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000348940111001005$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000348940111001005$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14131589$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11642423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeun, Eun-Ju</creatorcontrib><creatorcontrib>Park, Yong-Soo</creatorcontrib><creatorcontrib>Yeo, Sang W.</creatorcontrib><creatorcontrib>Choi, Young-Chul</creatorcontrib><creatorcontrib>Jung, Timothy T. K.</creatorcontrib><title>Effect of Inhibitor of Tumor Necrosis Factor-Alpha on Experimental Otitis Media with Effusion</title><title>Annals of otology, rhinology & laryngology</title><addtitle>Ann Otol Rhinol Laryngol</addtitle><description>Tumor necrosis factor (TNF)-α is important in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of TNF-α antagonist on the outcome of lipopolysaccharide (LPS)-induced OME in rats. Otitis media was induced by injecting Pseudomonas aeruginosa LPS transtympanically. Another (combination) group was pretreated with TNF-α antagonist, soluble TNF receptor type I (sTNF RI), before transtympanic injection of LPS. Saline and phosphate-buffered saline solutions were used as controls. Twelve hours after the transtympanic injection, otoscopic examination and aspiration of middle ear effusion (MEE) were done. The temporal bones in each group were examined histopathologically, and the vascular permeability of the middle ear mucosa was measured by the Evans blue vital dye technique. In the LPS and combination groups, MEE developed in 90% and 0% of ears, respectively. The combination group showed less inflammation, less mucosal thickening, and significantly decreased vascular permeability as compared to the LPS group. Transtympanic administration of sTNF RI appears to suppress the development of LPS-induced OME. This study suggests that TNF-α antagonist, along with antibiotics, may have an adjunctive role in the future treatment of MEE.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Ear, Middle - blood supply</subject><subject>Ent. Stomatology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Medical sciences</subject><subject>Mucous Membrane - blood supply</subject><subject>Non tumoral diseases</subject><subject>Otitis Media with Effusion - etiology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Tumor Necrosis Factor - physiology</subject><subject>Temporal Bone - pathology</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><issn>0003-4894</issn><issn>1943-572X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kF1LwzAUhoMobn78AS-kCHpXl5OmS3o5xqaD6W4meCMlSROX0Y_ZtKj_3pQVBgpCIHnJc95zzovQFeB7AMZGGOOI8oRiAMDYn_gIDSGhURgz8nqMhh0QdsQAnTm39ZLGmJyiAcCYEkqiIXqbGaNVE1QmWJQbK21T1Z1Yt4V_PGtVV866YC6U_wgn-W4jgqoMZl87XdtCl43Ig1VjG8886cyK4NM2m8Cbts5W5QU6MSJ3-rK_z9HLfLaePobL1cNiOlmGKkrGTaiwlIpGBEsFxFBOqWFAAESWcGGYYZxLmqlYMqlUpGnCDRtLraQXifCV5-hu77urq49WuyYtrFM6z0Wpq9aljBCgEWAP3vwCt1Vbl362lADjCY557CGyh7rlXa1NuvO7ivo7BZx2yad_k_dF171zKwudHUr6qD1w2wPCKZGbWpTKugNHIYKYJ54b7Tkn3vVhvH9a_wArKZfe</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Jeun, Eun-Ju</creator><creator>Park, Yong-Soo</creator><creator>Yeo, Sang W.</creator><creator>Choi, Young-Chul</creator><creator>Jung, Timothy T. 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K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-c0bbc4320bc12f4844f71211ad98af7f788b4dc5b7bcc3e498f76becbc3e9ac43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Ear, Middle - blood supply</topic><topic>Ent. Stomatology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Medical sciences</topic><topic>Mucous Membrane - blood supply</topic><topic>Non tumoral diseases</topic><topic>Otitis Media with Effusion - etiology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Tumor Necrosis Factor - physiology</topic><topic>Temporal Bone - pathology</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeun, Eun-Ju</creatorcontrib><creatorcontrib>Park, Yong-Soo</creatorcontrib><creatorcontrib>Yeo, Sang W.</creatorcontrib><creatorcontrib>Choi, Young-Chul</creatorcontrib><creatorcontrib>Jung, Timothy T. 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K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Inhibitor of Tumor Necrosis Factor-Alpha on Experimental Otitis Media with Effusion</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>110</volume><issue>10</issue><spage>917</spage><epage>921</epage><pages>917-921</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>Tumor necrosis factor (TNF)-α is important in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of TNF-α antagonist on the outcome of lipopolysaccharide (LPS)-induced OME in rats. Otitis media was induced by injecting Pseudomonas aeruginosa LPS transtympanically. Another (combination) group was pretreated with TNF-α antagonist, soluble TNF receptor type I (sTNF RI), before transtympanic injection of LPS. Saline and phosphate-buffered saline solutions were used as controls. Twelve hours after the transtympanic injection, otoscopic examination and aspiration of middle ear effusion (MEE) were done. The temporal bones in each group were examined histopathologically, and the vascular permeability of the middle ear mucosa was measured by the Evans blue vital dye technique. In the LPS and combination groups, MEE developed in 90% and 0% of ears, respectively. The combination group showed less inflammation, less mucosal thickening, and significantly decreased vascular permeability as compared to the LPS group. Transtympanic administration of sTNF RI appears to suppress the development of LPS-induced OME. This study suggests that TNF-α antagonist, along with antibiotics, may have an adjunctive role in the future treatment of MEE.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>11642423</pmid><doi>10.1177/000348940111001005</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2001-10, Vol.110 (10), p.917-921 |
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| subjects | Animals Biological and medical sciences Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Middle - blood supply Ent. Stomatology Lipopolysaccharides - pharmacology Medical sciences Mucous Membrane - blood supply Non tumoral diseases Otitis Media with Effusion - etiology Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, Tumor Necrosis Factor - physiology Temporal Bone - pathology Tumor Necrosis Factor-alpha - antagonists & inhibitors |
| title | Effect of Inhibitor of Tumor Necrosis Factor-Alpha on Experimental Otitis Media with Effusion |
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