Effect of antimicrobial mouthrinses on the in vitro adhesion of Candida albicans to human buccal epithelial cells
Adhesion to epithelial cells is a critical step in successful oral colonization and infection by Candida albicans. Therefore, three mouthrinse products, containing chlorhexidine 0.2% (CHX), cetylpyridinium chloride 0.05% (CPC) or triclosan 0.045% (TRN), were compared for their effects on the in vitr...
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| Veröffentlicht in: | Clinical oral investigations 2001-09, Vol.5 (3), p.172-176 |
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| container_title | Clinical oral investigations |
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| creator | Pizzo, G Giuliana, G Milici, M E D'Angelo, M |
| description | Adhesion to epithelial cells is a critical step in successful oral colonization and infection by Candida albicans. Therefore, three mouthrinse products, containing chlorhexidine 0.2% (CHX), cetylpyridinium chloride 0.05% (CPC) or triclosan 0.045% (TRN), were compared for their effects on the in vitro adhesion of C. albicans to human buccal epithelial cells (BEC). Candidal adhesion appeared to be significantly reduced by oral rinsing with the CHX-containing mouthrinse (P0.01). These findings suggest that mouthrinses containing CHX or CPC could be of value in the control of candidal colonization and infection. Clinical trials are warranted on the effectiveness of these products in reducing oral Candida carriage. |
| doi_str_mv | 10.1007/s007840100121 |
| format | Article |
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Therefore, three mouthrinse products, containing chlorhexidine 0.2% (CHX), cetylpyridinium chloride 0.05% (CPC) or triclosan 0.045% (TRN), were compared for their effects on the in vitro adhesion of C. albicans to human buccal epithelial cells (BEC). Candidal adhesion appeared to be significantly reduced by oral rinsing with the CHX-containing mouthrinse (P<0.0001). In vivo exposure of BEC to the CPC mouthrinse also inhibited adhesion of C. albicans (P<0.0001). Both CHX and CPC products suppressed adhesion to the same extent (P>0.01). On the other hand, the TRN mouthrinse did not significantly affect epithelial adhesion of C. albicans (P>0.01). These findings suggest that mouthrinses containing CHX or CPC could be of value in the control of candidal colonization and infection. Clinical trials are warranted on the effectiveness of these products in reducing oral Candida carriage.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s007840100121</identifier><identifier>PMID: 11642562</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Anti-Infective Agents, Local - pharmacology ; Candida albicans - drug effects ; Cell Adhesion - drug effects ; Cells, Cultured ; Cetylpyridinium - pharmacology ; Cheek ; Chlorhexidine - pharmacology ; Dentistry ; Epithelial Cells - microbiology ; Female ; Humans ; Male ; Mouth Mucosa - cytology ; Mouthwashes - pharmacology ; Statistics, Nonparametric ; Triclosan - pharmacology</subject><ispartof>Clinical oral investigations, 2001-09, Vol.5 (3), p.172-176</ispartof><rights>Springer-Verlag 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c231t-f97de56c69b88d85f0fb546e7739227686c0b5c5e15909666d66f71e1089dfbb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11642562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pizzo, G</creatorcontrib><creatorcontrib>Giuliana, G</creatorcontrib><creatorcontrib>Milici, M E</creatorcontrib><creatorcontrib>D'Angelo, M</creatorcontrib><title>Effect of antimicrobial mouthrinses on the in vitro adhesion of Candida albicans to human buccal epithelial cells</title><title>Clinical oral investigations</title><addtitle>Clin Oral Investig</addtitle><description>Adhesion to epithelial cells is a critical step in successful oral colonization and infection by Candida albicans. Therefore, three mouthrinse products, containing chlorhexidine 0.2% (CHX), cetylpyridinium chloride 0.05% (CPC) or triclosan 0.045% (TRN), were compared for their effects on the in vitro adhesion of C. albicans to human buccal epithelial cells (BEC). Candidal adhesion appeared to be significantly reduced by oral rinsing with the CHX-containing mouthrinse (P<0.0001). In vivo exposure of BEC to the CPC mouthrinse also inhibited adhesion of C. albicans (P<0.0001). Both CHX and CPC products suppressed adhesion to the same extent (P>0.01). On the other hand, the TRN mouthrinse did not significantly affect epithelial adhesion of C. albicans (P>0.01). These findings suggest that mouthrinses containing CHX or CPC could be of value in the control of candidal colonization and infection. Clinical trials are warranted on the effectiveness of these products in reducing oral Candida carriage.</description><subject>Adult</subject><subject>Anti-Infective Agents, Local - pharmacology</subject><subject>Candida albicans - drug effects</subject><subject>Cell Adhesion - drug effects</subject><subject>Cells, Cultured</subject><subject>Cetylpyridinium - pharmacology</subject><subject>Cheek</subject><subject>Chlorhexidine - pharmacology</subject><subject>Dentistry</subject><subject>Epithelial Cells - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mouth Mucosa - cytology</subject><subject>Mouthwashes - pharmacology</subject><subject>Statistics, Nonparametric</subject><subject>Triclosan - pharmacology</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkctLAzEQxoMotlaPXiV48Laax24eRyn1AQUvel6SbMKm7CbtZlfwvze1BdHLzDD8vo-PGQCuMbrHCPGHlIsoUZ4xwSdgjkvKCso5Pv2ZScGkwDNwkdImIyXj9BzMMGYlqRiZg93KOWtGGB1UYfS9N0PUXnWwj9PYDj4km2AMcGwt9AF--nGIUDWtTT5vs2qpQuMbBVWnvVEhwTHCdupVgHoyJhvZrc_ibu9pbNelS3DmVJfs1bEvwMfT6n35Uqzfnl-Xj-vCEIrHwkne2IoZJrUQjagccroqmeWcSkI4E8wgXZnK4koiyRhrGHMcW4yEbJzWdAHuDr7bIe4mm8a692mfQAUbp1RzQjAlEmXw9h-4idMQcraaEMmIIJXMUHGA8n1SGqyrt4Pv1fBVY1TvH1H_eUTmb46mk-5t80sfL0-_AZ-4gtU</recordid><startdate>200109</startdate><enddate>200109</enddate><creator>Pizzo, G</creator><creator>Giuliana, G</creator><creator>Milici, M E</creator><creator>D'Angelo, M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200109</creationdate><title>Effect of antimicrobial mouthrinses on the in vitro adhesion of Candida albicans to human buccal epithelial cells</title><author>Pizzo, G ; 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Therefore, three mouthrinse products, containing chlorhexidine 0.2% (CHX), cetylpyridinium chloride 0.05% (CPC) or triclosan 0.045% (TRN), were compared for their effects on the in vitro adhesion of C. albicans to human buccal epithelial cells (BEC). Candidal adhesion appeared to be significantly reduced by oral rinsing with the CHX-containing mouthrinse (P<0.0001). In vivo exposure of BEC to the CPC mouthrinse also inhibited adhesion of C. albicans (P<0.0001). Both CHX and CPC products suppressed adhesion to the same extent (P>0.01). On the other hand, the TRN mouthrinse did not significantly affect epithelial adhesion of C. albicans (P>0.01). These findings suggest that mouthrinses containing CHX or CPC could be of value in the control of candidal colonization and infection. 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| subjects | Adult Anti-Infective Agents, Local - pharmacology Candida albicans - drug effects Cell Adhesion - drug effects Cells, Cultured Cetylpyridinium - pharmacology Cheek Chlorhexidine - pharmacology Dentistry Epithelial Cells - microbiology Female Humans Male Mouth Mucosa - cytology Mouthwashes - pharmacology Statistics, Nonparametric Triclosan - pharmacology |
| title | Effect of antimicrobial mouthrinses on the in vitro adhesion of Candida albicans to human buccal epithelial cells |
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