Phosphorylation-dependent Regulation of the Interaction of Amyloid Precursor Protein with Fe65 Affects the Production of β-Amyloid

Neuronal Fe65 is an adapter protein that interacts with the cytoplasmic domain of the β-amyloid precursor protein (APP). Although the interaction has been reported to occur between the second phosphotyrosine interaction domain of Fe65 and the YENPTY motif in the cytoplasmic domain of APP, the regula...

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Veröffentlicht in:	The Journal of biological chemistry 2001-10, Vol.276 (43), p.40353-40361
Hauptverfasser:	Ando, Kanae, Iijima, Ko-ichi, Elliott, James I., Kirino, Yutaka, Suzuki, Toshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Alzheimer Disease - etiology Amino Acid Motifs Amyloid beta-Peptides - biosynthesis Amyloid beta-Protein Precursor - metabolism Binding Sites Humans Nerve Tissue Proteins - metabolism Nuclear Proteins - metabolism Phosphorylation Protein Binding Protein Conformation Protein Structure, Tertiary Threonine - metabolism Two-Hybrid System Techniques
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