Using DNA fingerprinting to detect transmission of Mycobacterium tuberculosis among AIDS patients in two health-care facilities in Puerto Rico
Fourteen cases of tuberculosis (TB) in Puerto Rico, diagnosed from April 1993 to April 1995, had the same DNA fingerprint, documenting disease caused by the same strain of Mycobacterium tuberculosis. The 14 cases were retrospectively investigated for epidemiologic links. Records were reviewed and st...
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| Veröffentlicht in: | Southern medical journal (Birmingham, Ala.) Ala.), 2000-08, Vol.93 (8), p.777-782 |
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| container_title | Southern medical journal (Birmingham, Ala.) |
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| creator | HENNESSEY, K. A SCHULTE, J. M VALWAY, S. E JOGLAR, O. T RIOS, N SHEPPARD, J. D ONORATO, I. M |
| description | Fourteen cases of tuberculosis (TB) in Puerto Rico, diagnosed from April 1993 to April 1995, had the same DNA fingerprint, documenting disease caused by the same strain of Mycobacterium tuberculosis. The 14 cases were retrospectively investigated for epidemiologic links.
Records were reviewed and staffs of the TB program, hospital/clinic, and AIDS residential facilities were interviewed.
Half of the AIDS cases were epidemiologically related, providing evidence of TB transmission in an emergency department, an AIDS inpatient ward, and an AIDS residential facility. DNA fingerprinting allowed detection of M tuberculosis transmission, but contact investigators could have documented it sooner. Factors contributing to transmission included delayed diagnosis, prolonged infectiousness, inadequate discharge planning and infection control procedures, and poor communication between health-care facilities.
The numbers of AIDS residential facilities are increasing and must understand proper monitoring of TB patients and infection control measures that prevent transmissions. |
| doi_str_mv | 10.1097/00007611-200008000-00007 |
| format | Article |
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Records were reviewed and staffs of the TB program, hospital/clinic, and AIDS residential facilities were interviewed.
Half of the AIDS cases were epidemiologically related, providing evidence of TB transmission in an emergency department, an AIDS inpatient ward, and an AIDS residential facility. DNA fingerprinting allowed detection of M tuberculosis transmission, but contact investigators could have documented it sooner. Factors contributing to transmission included delayed diagnosis, prolonged infectiousness, inadequate discharge planning and infection control procedures, and poor communication between health-care facilities.
The numbers of AIDS residential facilities are increasing and must understand proper monitoring of TB patients and infection control measures that prevent transmissions.</description><identifier>ISSN: 0038-4348</identifier><identifier>EISSN: 1541-8243</identifier><identifier>DOI: 10.1097/00007611-200008000-00007</identifier><identifier>PMID: 10963508</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>AIDS-Related Opportunistic Infections - epidemiology ; AIDS-Related Opportunistic Infections - microbiology ; AIDS-Related Opportunistic Infections - transmission ; AIDS/HIV ; Biological and medical sciences ; Cluster Analysis ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Cross Infection - prevention & control ; Cross Infection - transmission ; Disease Outbreaks - prevention & control ; Disease Outbreaks - statistics & numerical data ; DNA Fingerprinting - methods ; DNA, Bacterial - analysis ; DNA, Bacterial - genetics ; Female ; Human viral diseases ; Humans ; Infection Control ; Infectious diseases ; Male ; Medical sciences ; Molecular Epidemiology ; Mycobacterium tuberculosis - genetics ; Puerto Rico - epidemiology ; Retrospective Studies ; Risk Factors ; Seasons ; Surveys and Questionnaires ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Tuberculosis - prevention & control ; Tuberculosis - transmission ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Southern medical journal (Birmingham, Ala.), 2000-08, Vol.93 (8), p.777-782</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1455944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10963508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HENNESSEY, K. A</creatorcontrib><creatorcontrib>SCHULTE, J. M</creatorcontrib><creatorcontrib>VALWAY, S. E</creatorcontrib><creatorcontrib>JOGLAR, O. T</creatorcontrib><creatorcontrib>RIOS, N</creatorcontrib><creatorcontrib>SHEPPARD, J. D</creatorcontrib><creatorcontrib>ONORATO, I. M</creatorcontrib><title>Using DNA fingerprinting to detect transmission of Mycobacterium tuberculosis among AIDS patients in two health-care facilities in Puerto Rico</title><title>Southern medical journal (Birmingham, Ala.)</title><addtitle>South Med J</addtitle><description>Fourteen cases of tuberculosis (TB) in Puerto Rico, diagnosed from April 1993 to April 1995, had the same DNA fingerprint, documenting disease caused by the same strain of Mycobacterium tuberculosis. The 14 cases were retrospectively investigated for epidemiologic links.
Records were reviewed and staffs of the TB program, hospital/clinic, and AIDS residential facilities were interviewed.
Half of the AIDS cases were epidemiologically related, providing evidence of TB transmission in an emergency department, an AIDS inpatient ward, and an AIDS residential facility. DNA fingerprinting allowed detection of M tuberculosis transmission, but contact investigators could have documented it sooner. Factors contributing to transmission included delayed diagnosis, prolonged infectiousness, inadequate discharge planning and infection control procedures, and poor communication between health-care facilities.
The numbers of AIDS residential facilities are increasing and must understand proper monitoring of TB patients and infection control measures that prevent transmissions.</description><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>AIDS-Related Opportunistic Infections - microbiology</subject><subject>AIDS-Related Opportunistic Infections - transmission</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cluster Analysis</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - prevention & control</subject><subject>Cross Infection - transmission</subject><subject>Disease Outbreaks - prevention & control</subject><subject>Disease Outbreaks - statistics & numerical data</subject><subject>DNA Fingerprinting - methods</subject><subject>DNA, Bacterial - analysis</subject><subject>DNA, Bacterial - genetics</subject><subject>Female</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infection Control</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Epidemiology</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Puerto Rico - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Seasons</subject><subject>Surveys and Questionnaires</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis - transmission</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0038-4348</issn><issn>1541-8243</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUV1P3DAQtKqictD-hcoPqG8Bf8bO4wloiwQFQXmONr5NcZXEh-2o4k_0N-PjrgVLllezM7vyDCGUs2POGnPCyjE155XYVLbc6gV6RxZcK15ZoeR7smBM2kpJZffJQUq_Nwxt6w9kvwyppWZ2Qf7eJz_9omc_lrQvBcZ19FPeQDnQFWZ0meYIUxp9Sj5MNPT06smFDlzG6OeR5rnD6OYhJJ8ojKFIlxdnd3QN2eOUE_UTzX8CfUAY8kPlICLtwfnBl_5L92bGWLbdehc-kr0ehoSfdu8huf96_vP0e3V5_e3idHlZOcFNrrSQjTF90zneOAEWmNaacURsGFNCGFaDQIDGcGZULTqlFRirHV85K7WTh-TLdu46hscZU27L_xwOA0wY5tQaIbiwkhei3RJdDClF7Nti0AjxqeWs3WTR_sui_Z_FFirSz7sdczfi6o1wa34hHO0IkBwMfbHZ-fTKU1o3Ssln0_OSXQ</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>HENNESSEY, K. A</creator><creator>SCHULTE, J. M</creator><creator>VALWAY, S. E</creator><creator>JOGLAR, O. T</creator><creator>RIOS, N</creator><creator>SHEPPARD, J. D</creator><creator>ONORATO, I. 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Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HENNESSEY, K. A</creatorcontrib><creatorcontrib>SCHULTE, J. M</creatorcontrib><creatorcontrib>VALWAY, S. E</creatorcontrib><creatorcontrib>JOGLAR, O. T</creatorcontrib><creatorcontrib>RIOS, N</creatorcontrib><creatorcontrib>SHEPPARD, J. D</creatorcontrib><creatorcontrib>ONORATO, I. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HENNESSEY, K. A</au><au>SCHULTE, J. M</au><au>VALWAY, S. E</au><au>JOGLAR, O. T</au><au>RIOS, N</au><au>SHEPPARD, J. D</au><au>ONORATO, I. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using DNA fingerprinting to detect transmission of Mycobacterium tuberculosis among AIDS patients in two health-care facilities in Puerto Rico</atitle><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle><addtitle>South Med J</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>93</volume><issue>8</issue><spage>777</spage><epage>782</epage><pages>777-782</pages><issn>0038-4348</issn><eissn>1541-8243</eissn><abstract>Fourteen cases of tuberculosis (TB) in Puerto Rico, diagnosed from April 1993 to April 1995, had the same DNA fingerprint, documenting disease caused by the same strain of Mycobacterium tuberculosis. The 14 cases were retrospectively investigated for epidemiologic links.
Records were reviewed and staffs of the TB program, hospital/clinic, and AIDS residential facilities were interviewed.
Half of the AIDS cases were epidemiologically related, providing evidence of TB transmission in an emergency department, an AIDS inpatient ward, and an AIDS residential facility. DNA fingerprinting allowed detection of M tuberculosis transmission, but contact investigators could have documented it sooner. Factors contributing to transmission included delayed diagnosis, prolonged infectiousness, inadequate discharge planning and infection control procedures, and poor communication between health-care facilities.
The numbers of AIDS residential facilities are increasing and must understand proper monitoring of TB patients and infection control measures that prevent transmissions.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10963508</pmid><doi>10.1097/00007611-200008000-00007</doi><tpages>6</tpages></addata></record> |
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| ispartof | Southern medical journal (Birmingham, Ala.), 2000-08, Vol.93 (8), p.777-782 |
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| subjects | AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - microbiology AIDS-Related Opportunistic Infections - transmission AIDS/HIV Biological and medical sciences Cluster Analysis Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - prevention & control Cross Infection - transmission Disease Outbreaks - prevention & control Disease Outbreaks - statistics & numerical data DNA Fingerprinting - methods DNA, Bacterial - analysis DNA, Bacterial - genetics Female Human viral diseases Humans Infection Control Infectious diseases Male Medical sciences Molecular Epidemiology Mycobacterium tuberculosis - genetics Puerto Rico - epidemiology Retrospective Studies Risk Factors Seasons Surveys and Questionnaires Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis - prevention & control Tuberculosis - transmission Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Using DNA fingerprinting to detect transmission of Mycobacterium tuberculosis among AIDS patients in two health-care facilities in Puerto Rico |
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