Influence of Maternal Antibodies on Neonatal Immunization against Respiratory Viruses
Vaccines that successfully prevent severe infant respiratory virus diseases should induce protection at a very young age because of the low age of patients who are hospitalized owing to these viruses. Candidate respiratory virus vaccines are being tested in infants who are naïve to infection but ser...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 2001-11, Vol.33 (10), p.1720-1727 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1727 |
|---|---|
| container_issue | 10 |
| container_start_page | 1720 |
| container_title | Clinical infectious diseases |
| container_volume | 33 |
| creator | Gellin, Bruce Modlin, John F. Crowe, James E. |
| description | Vaccines that successfully prevent severe infant respiratory virus diseases should induce protection at a very young age because of the low age of patients who are hospitalized owing to these viruses. Candidate respiratory virus vaccines are being tested in infants who are naïve to infection but seropositive to the viral agents because they possess maternal IgG antibodies (Abs). Transplacental maternal Abs may be partially protective against disease caused by respiratory virus infections. Carefully conducted studies have shown that these Abs can also profoundly suppress or enhance infant immune responses to immunization. The mechanisms underlying regulation of immune responses to viruses by maternal Abs are under investigation. This article explores the current knowledge regarding the effect of maternal Abs on respiratory virus and measles virus immunization, and it reviews the current approaches to overcoming Ab-mediated immunosuppression. |
| doi_str_mv | 10.1086/322971 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72212632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4482873</jstor_id><oup_id>10.1086/322971</oup_id><sourcerecordid>4482873</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-3ca16f728f4927fd8956a073804122ffb8b1c486b4f775d9245475f3f5b680b63</originalsourceid><addsrcrecordid>eNqF0Etv1DAQB3ALUdEXfAKEwgFuoR6_c6yq0t2qvOmCuFhO1kYuib21HYny6UmVVfeEOI0189OM9UfoGeA3gJU4oYQ0Eh6hA-BU1oI38Hh6Y65qpqjaR4c532AMoDB_gvYBeMMbJQ7Q9TK4frShs1V01TtTbAqmr05D8W1ce5urGKr3NgZTpvZyGMbg_5jip675aXzIpfps88YnU2K6q1Y-jdnmY7TnTJ_t0209Qtdvz7-eLeqrDxfLs9OrumOclpp2BoSTRDnWEOnWquHCYEkVZkCIc61qoWNKtMxJydcNYZxJ7qjjrVC4FfQIvZ73blK8HW0uevC5s31vgo1j1pIQIIKS_0JQjIOkdAe7FHNO1ulN8oNJdxqwvk9az0lP8MV249gOdr1j22gn8GoLTO5M75IJnc87x4A2VKjJvZxdHDf_PvZ8Njd5ivlBMaaIkvefruexz8X-fhib9EsLSSXXi-8_9OLLp9UKLj_qb_Qv0eKnDA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18451733</pqid></control><display><type>article</type><title>Influence of Maternal Antibodies on Neonatal Immunization against Respiratory Viruses</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Gellin, Bruce ; Modlin, John F. ; Crowe, James E.</creator><creatorcontrib>Gellin, Bruce ; Modlin, John F. ; Crowe, James E.</creatorcontrib><description>Vaccines that successfully prevent severe infant respiratory virus diseases should induce protection at a very young age because of the low age of patients who are hospitalized owing to these viruses. Candidate respiratory virus vaccines are being tested in infants who are naïve to infection but seropositive to the viral agents because they possess maternal IgG antibodies (Abs). Transplacental maternal Abs may be partially protective against disease caused by respiratory virus infections. Carefully conducted studies have shown that these Abs can also profoundly suppress or enhance infant immune responses to immunization. The mechanisms underlying regulation of immune responses to viruses by maternal Abs are under investigation. This article explores the current knowledge regarding the effect of maternal Abs on respiratory virus and measles virus immunization, and it reviews the current approaches to overcoming Ab-mediated immunosuppression.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/322971</identifier><identifier>PMID: 11595986</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibodies ; Antibodies, Viral - immunology ; B lymphocytes ; Biological and medical sciences ; Female ; General aspects ; Human respiratory syncytial virus ; Humans ; Immunity, Maternally-Acquired ; Immunization ; Infant, Newborn ; Infants ; Infections ; Infectious diseases ; Measles virus ; Medical sciences ; Respiratory Syncytial Virus Infections - prevention & control ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Virus Vaccines - administration & dosage ; Respiratory Syncytial Virus Vaccines - immunology ; Respiratory Syncytial Viruses - immunology ; Respiratory Tract Infections - prevention & control ; Respiratory Tract Infections - virology ; T lymphocytes ; Vaccination ; Vaccines ; Viral diseases ; Viruses</subject><ispartof>Clinical infectious diseases, 2001-11, Vol.33 (10), p.1720-1727</ispartof><rights>Copyright 2001 The Infectious Diseases Society of America</rights><rights>2001 by the Infectious Diseases Society of America 2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-3ca16f728f4927fd8956a073804122ffb8b1c486b4f775d9245475f3f5b680b63</citedby><cites>FETCH-LOGICAL-c453t-3ca16f728f4927fd8956a073804122ffb8b1c486b4f775d9245475f3f5b680b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4482873$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4482873$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14139368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11595986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gellin, Bruce</creatorcontrib><creatorcontrib>Modlin, John F.</creatorcontrib><creatorcontrib>Crowe, James E.</creatorcontrib><title>Influence of Maternal Antibodies on Neonatal Immunization against Respiratory Viruses</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Vaccines that successfully prevent severe infant respiratory virus diseases should induce protection at a very young age because of the low age of patients who are hospitalized owing to these viruses. Candidate respiratory virus vaccines are being tested in infants who are naïve to infection but seropositive to the viral agents because they possess maternal IgG antibodies (Abs). Transplacental maternal Abs may be partially protective against disease caused by respiratory virus infections. Carefully conducted studies have shown that these Abs can also profoundly suppress or enhance infant immune responses to immunization. The mechanisms underlying regulation of immune responses to viruses by maternal Abs are under investigation. This article explores the current knowledge regarding the effect of maternal Abs on respiratory virus and measles virus immunization, and it reviews the current approaches to overcoming Ab-mediated immunosuppression.</description><subject>Antibodies</subject><subject>Antibodies, Viral - immunology</subject><subject>B lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>General aspects</subject><subject>Human respiratory syncytial virus</subject><subject>Humans</subject><subject>Immunity, Maternally-Acquired</subject><subject>Immunization</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Measles virus</subject><subject>Medical sciences</subject><subject>Respiratory Syncytial Virus Infections - prevention & control</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory Syncytial Virus Vaccines - administration & dosage</subject><subject>Respiratory Syncytial Virus Vaccines - immunology</subject><subject>Respiratory Syncytial Viruses - immunology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Respiratory Tract Infections - virology</subject><subject>T lymphocytes</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Etv1DAQB3ALUdEXfAKEwgFuoR6_c6yq0t2qvOmCuFhO1kYuib21HYny6UmVVfeEOI0189OM9UfoGeA3gJU4oYQ0Eh6hA-BU1oI38Hh6Y65qpqjaR4c532AMoDB_gvYBeMMbJQ7Q9TK4frShs1V01TtTbAqmr05D8W1ce5urGKr3NgZTpvZyGMbg_5jip675aXzIpfps88YnU2K6q1Y-jdnmY7TnTJ_t0209Qtdvz7-eLeqrDxfLs9OrumOclpp2BoSTRDnWEOnWquHCYEkVZkCIc61qoWNKtMxJydcNYZxJ7qjjrVC4FfQIvZ73blK8HW0uevC5s31vgo1j1pIQIIKS_0JQjIOkdAe7FHNO1ulN8oNJdxqwvk9az0lP8MV249gOdr1j22gn8GoLTO5M75IJnc87x4A2VKjJvZxdHDf_PvZ8Njd5ivlBMaaIkvefruexz8X-fhib9EsLSSXXi-8_9OLLp9UKLj_qb_Qv0eKnDA</recordid><startdate>20011115</startdate><enddate>20011115</enddate><creator>Gellin, Bruce</creator><creator>Modlin, John F.</creator><creator>Crowe, James E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20011115</creationdate><title>Influence of Maternal Antibodies on Neonatal Immunization against Respiratory Viruses</title><author>Gellin, Bruce ; Modlin, John F. ; Crowe, James E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-3ca16f728f4927fd8956a073804122ffb8b1c486b4f775d9245475f3f5b680b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antibodies</topic><topic>Antibodies, Viral - immunology</topic><topic>B lymphocytes</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>General aspects</topic><topic>Human respiratory syncytial virus</topic><topic>Humans</topic><topic>Immunity, Maternally-Acquired</topic><topic>Immunization</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Measles virus</topic><topic>Medical sciences</topic><topic>Respiratory Syncytial Virus Infections - prevention & control</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory Syncytial Virus Vaccines - administration & dosage</topic><topic>Respiratory Syncytial Virus Vaccines - immunology</topic><topic>Respiratory Syncytial Viruses - immunology</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Respiratory Tract Infections - virology</topic><topic>T lymphocytes</topic><topic>Vaccination</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gellin, Bruce</creatorcontrib><creatorcontrib>Modlin, John F.</creatorcontrib><creatorcontrib>Crowe, James E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gellin, Bruce</au><au>Modlin, John F.</au><au>Crowe, James E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Maternal Antibodies on Neonatal Immunization against Respiratory Viruses</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2001-11-15</date><risdate>2001</risdate><volume>33</volume><issue>10</issue><spage>1720</spage><epage>1727</epage><pages>1720-1727</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Vaccines that successfully prevent severe infant respiratory virus diseases should induce protection at a very young age because of the low age of patients who are hospitalized owing to these viruses. Candidate respiratory virus vaccines are being tested in infants who are naïve to infection but seropositive to the viral agents because they possess maternal IgG antibodies (Abs). Transplacental maternal Abs may be partially protective against disease caused by respiratory virus infections. Carefully conducted studies have shown that these Abs can also profoundly suppress or enhance infant immune responses to immunization. The mechanisms underlying regulation of immune responses to viruses by maternal Abs are under investigation. This article explores the current knowledge regarding the effect of maternal Abs on respiratory virus and measles virus immunization, and it reviews the current approaches to overcoming Ab-mediated immunosuppression.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11595986</pmid><doi>10.1086/322971</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2001-11, Vol.33 (10), p.1720-1727 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72212632 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Antibodies Antibodies, Viral - immunology B lymphocytes Biological and medical sciences Female General aspects Human respiratory syncytial virus Humans Immunity, Maternally-Acquired Immunization Infant, Newborn Infants Infections Infectious diseases Measles virus Medical sciences Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus Vaccines - administration & dosage Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Viruses - immunology Respiratory Tract Infections - prevention & control Respiratory Tract Infections - virology T lymphocytes Vaccination Vaccines Viral diseases Viruses |
| title | Influence of Maternal Antibodies on Neonatal Immunization against Respiratory Viruses |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T06%3A04%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Maternal%20Antibodies%20on%20Neonatal%20Immunization%20against%20Respiratory%20Viruses&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Gellin,%20Bruce&rft.date=2001-11-15&rft.volume=33&rft.issue=10&rft.spage=1720&rft.epage=1727&rft.pages=1720-1727&rft.issn=1058-4838&rft.eissn=1537-6591&rft.coden=CIDIEL&rft_id=info:doi/10.1086/322971&rft_dat=%3Cjstor_proqu%3E4482873%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18451733&rft_id=info:pmid/11595986&rft_jstor_id=4482873&rft_oup_id=10.1086/322971&rfr_iscdi=true |