Role of Pax3/7 in the tectum regionalization
Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7 in the tectum development, we misexpressed Pax3 and Pa...
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| Veröffentlicht in: | Development (Cambridge) 2001-10, Vol.128 (20), p.4069-4077 |
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| creator | Matsunaga, E Araki, I Nakamura, H |
| description | Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7 in the tectum development, we misexpressed Pax3 and Pax7 in the diencephalon and ventral mesencephalon. Morphological and molecular marker gene analysis indicated that Pax3 and Pax7 misexpression caused fate change of the alar plate of the presumptive diencephalon to that of the mesencephalon, that is, a tectum and a torus semicircularis were formed ectopically. Ectopic tectum in the diencephalon appeared to be generated through sequential induction of Fgf8 , En2 and Pax3/7 . In ventral mesencephalon, which expresses En but does not differentiate to the tectum in normal development, Pax3 and Pax7 misexpression induced ectopic tectum. In normal development, Pax3 and Pax7 expression in the mesencephalon commences after Otx2 , En and Pax2/5 expression. In addition, expression domain of Pax3 and Pax7 is well consistent with presumptive tectum region in a dorsoventral axis. Taken together with normal expression pattern of Pax3 and Pax7 , results of misexpression experiments suggest that Pax3 and Pax7 define the tectum region subsequent to the function of Otx2 and En . |
| doi_str_mv | 10.1242/dev.128.20.4069 |
| format | Article |
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The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7 in the tectum development, we misexpressed Pax3 and Pax7 in the diencephalon and ventral mesencephalon. Morphological and molecular marker gene analysis indicated that Pax3 and Pax7 misexpression caused fate change of the alar plate of the presumptive diencephalon to that of the mesencephalon, that is, a tectum and a torus semicircularis were formed ectopically. Ectopic tectum in the diencephalon appeared to be generated through sequential induction of Fgf8 , En2 and Pax3/7 . In ventral mesencephalon, which expresses En but does not differentiate to the tectum in normal development, Pax3 and Pax7 misexpression induced ectopic tectum. In normal development, Pax3 and Pax7 expression in the mesencephalon commences after Otx2 , En and Pax2/5 expression. In addition, expression domain of Pax3 and Pax7 is well consistent with presumptive tectum region in a dorsoventral axis. Taken together with normal expression pattern of Pax3 and Pax7 , results of misexpression experiments suggest that Pax3 and Pax7 define the tectum region subsequent to the function of Otx2 and En .</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.128.20.4069</identifier><identifier>PMID: 11641229</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Animals ; Chick Embryo ; Diencephalon - embryology ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - physiology ; Fibroblast Growth Factor 8 ; Fibroblast Growth Factors - genetics ; Fibroblast Growth Factors - physiology ; Gene Expression Regulation, Developmental ; Homeodomain Proteins - genetics ; Homeodomain Proteins - physiology ; Mesencephalon - embryology ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Otx Transcription Factors ; Otx2 gene ; Paired Box Transcription Factors ; Pax3 gene ; PAX3 Transcription Factor ; Pax7 gene ; PAX7 Transcription Factor ; Prosencephalon - embryology ; Superior Colliculi - embryology ; Trans-Activators - genetics ; Trans-Activators - physiology ; Transcription Factors</subject><ispartof>Development (Cambridge), 2001-10, Vol.128 (20), p.4069-4077</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-d1d7659735499d7c3f3cf499410dd5131863ef89753e5702065ade3924727e4c3</citedby><cites>FETCH-LOGICAL-c363t-d1d7659735499d7c3f3cf499410dd5131863ef89753e5702065ade3924727e4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3665,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11641229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsunaga, E</creatorcontrib><creatorcontrib>Araki, I</creatorcontrib><creatorcontrib>Nakamura, H</creatorcontrib><title>Role of Pax3/7 in the tectum regionalization</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7 in the tectum development, we misexpressed Pax3 and Pax7 in the diencephalon and ventral mesencephalon. Morphological and molecular marker gene analysis indicated that Pax3 and Pax7 misexpression caused fate change of the alar plate of the presumptive diencephalon to that of the mesencephalon, that is, a tectum and a torus semicircularis were formed ectopically. Ectopic tectum in the diencephalon appeared to be generated through sequential induction of Fgf8 , En2 and Pax3/7 . In ventral mesencephalon, which expresses En but does not differentiate to the tectum in normal development, Pax3 and Pax7 misexpression induced ectopic tectum. In normal development, Pax3 and Pax7 expression in the mesencephalon commences after Otx2 , En and Pax2/5 expression. In addition, expression domain of Pax3 and Pax7 is well consistent with presumptive tectum region in a dorsoventral axis. Taken together with normal expression pattern of Pax3 and Pax7 , results of misexpression experiments suggest that Pax3 and Pax7 define the tectum region subsequent to the function of Otx2 and En .</description><subject>Animals</subject><subject>Chick Embryo</subject><subject>Diencephalon - embryology</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Fibroblast Growth Factor 8</subject><subject>Fibroblast Growth Factors - genetics</subject><subject>Fibroblast Growth Factors - physiology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - physiology</subject><subject>Mesencephalon - embryology</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Otx Transcription Factors</subject><subject>Otx2 gene</subject><subject>Paired Box Transcription Factors</subject><subject>Pax3 gene</subject><subject>PAX3 Transcription Factor</subject><subject>Pax7 gene</subject><subject>PAX7 Transcription Factor</subject><subject>Prosencephalon - embryology</subject><subject>Superior Colliculi - embryology</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - physiology</subject><subject>Transcription Factors</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EoqUws6FMTCS1r-04HhHiJVUCIZitNL5pjZK6xAmvX4-rVkJMTPcM557hI-SU0YyBgKnF9whFBjQTNNd7ZMyEUqlmoPfJmGpJU6Y1G5GjEF4ppTxX6pCMGMsFA9BjcvHkG0x8nTyWn3yqErdK-iUmPVb90CYdLpxflY37LvsIx-SgLpuAJ7s7IS83189Xd-ns4fb-6nKWVjznfWqZVbnUikuhtVUVr3lVRxSMWisZZ0XOsS60khylokBzWVrkGoQChaLiE3K-7a47_zZg6E3rQoVNU67QD8EoAAaS039FVgCALEQUp1ux6nwIHdZm3bm27L4Mo2azpIlLRigMULNZMn6c7dLDvEX76--mi0K2FZZusfxwHZq5841fuNCHTQ0bv_5T_AGTvnvZ</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Matsunaga, E</creator><creator>Araki, I</creator><creator>Nakamura, H</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Role of Pax3/7 in the tectum regionalization</title><author>Matsunaga, E ; Araki, I ; Nakamura, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-d1d7659735499d7c3f3cf499410dd5131863ef89753e5702065ade3924727e4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Chick Embryo</topic><topic>Diencephalon - embryology</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Fibroblast Growth Factor 8</topic><topic>Fibroblast Growth Factors - genetics</topic><topic>Fibroblast Growth Factors - physiology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - physiology</topic><topic>Mesencephalon - embryology</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Otx Transcription Factors</topic><topic>Otx2 gene</topic><topic>Paired Box Transcription Factors</topic><topic>Pax3 gene</topic><topic>PAX3 Transcription Factor</topic><topic>Pax7 gene</topic><topic>PAX7 Transcription Factor</topic><topic>Prosencephalon - embryology</topic><topic>Superior Colliculi - embryology</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - physiology</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsunaga, E</creatorcontrib><creatorcontrib>Araki, I</creatorcontrib><creatorcontrib>Nakamura, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsunaga, E</au><au>Araki, I</au><au>Nakamura, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Pax3/7 in the tectum regionalization</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>128</volume><issue>20</issue><spage>4069</spage><epage>4077</epage><pages>4069-4077</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7 in the tectum development, we misexpressed Pax3 and Pax7 in the diencephalon and ventral mesencephalon. Morphological and molecular marker gene analysis indicated that Pax3 and Pax7 misexpression caused fate change of the alar plate of the presumptive diencephalon to that of the mesencephalon, that is, a tectum and a torus semicircularis were formed ectopically. Ectopic tectum in the diencephalon appeared to be generated through sequential induction of Fgf8 , En2 and Pax3/7 . In ventral mesencephalon, which expresses En but does not differentiate to the tectum in normal development, Pax3 and Pax7 misexpression induced ectopic tectum. In normal development, Pax3 and Pax7 expression in the mesencephalon commences after Otx2 , En and Pax2/5 expression. In addition, expression domain of Pax3 and Pax7 is well consistent with presumptive tectum region in a dorsoventral axis. Taken together with normal expression pattern of Pax3 and Pax7 , results of misexpression experiments suggest that Pax3 and Pax7 define the tectum region subsequent to the function of Otx2 and En .</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>11641229</pmid><doi>10.1242/dev.128.20.4069</doi><tpages>9</tpages></addata></record> |
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| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Chick Embryo Diencephalon - embryology DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Fibroblast Growth Factor 8 Fibroblast Growth Factors - genetics Fibroblast Growth Factors - physiology Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - physiology Mesencephalon - embryology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Otx Transcription Factors Otx2 gene Paired Box Transcription Factors Pax3 gene PAX3 Transcription Factor Pax7 gene PAX7 Transcription Factor Prosencephalon - embryology Superior Colliculi - embryology Trans-Activators - genetics Trans-Activators - physiology Transcription Factors |
| title | Role of Pax3/7 in the tectum regionalization |
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