c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer
A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viabilit...
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| Veröffentlicht in: | Acta biochimica polonica 2000-01, Vol.47 (1), p.149-156 |
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| container_title | Acta biochimica polonica |
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| creator | Falkiewicz, B Schlotter, C M Bosse, U Bielawski, K Vogt, U |
| description | A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations. |
| doi_str_mv | 10.18388/abp.2000_4072 |
| format | Article |
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Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. 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Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>Breast Neoplasms - genetics</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>DNA - metabolism</subject><subject>Female</subject><subject>Gene Dosage</subject><subject>Genes, myc</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Mucin-1 - blood</subject><issn>0001-527X</issn><issn>1734-154X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUU1P3DAQtaqisqW9ckRz6oks_sjGyXG1pS0SgksrcYsmzgSMEnuxk6j7b_ipuLurisvMaN6bpzd6jJ0LvhSlKssrbLZLyTmvc67lB7YQWuWZWOUPH9kirUW2kvrhlH2O8ZlzqUSVf2KngleFKMpywV5NNuwMeGf8IzmCfWl9xEe6hEhhGmBzvQZ0LWzWSXep0jzaRIOeZurj5R4z1PdTjwG-361hxn6iCNZBoB5H6x2MHugvzHb2YJ5o8JFctKOd7bgD38E22AHDDp6mAR00gTCOYNAZCl_YSYd9pK_Hfsb-_Lj-vfmV3d7_vNmsbzMjKzFmqujaSpuiadEI2aGSXJSGy26lZdOQKrSSggqdoLbC1iiUClGrrssxV6JRZ-zbQXcb_EuyP9aDjf_eQkd-irWWUgitV4m4PBBN8DEG6uqj-1rwep9JnTKp_2eSDi6OylMzUPuOfghBvQE_NImK</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Falkiewicz, B</creator><creator>Schlotter, C M</creator><creator>Bosse, U</creator><creator>Bielawski, K</creator><creator>Vogt, U</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer</title><author>Falkiewicz, B ; Schlotter, C M ; Bosse, U ; Bielawski, K ; Vogt, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-36fd97c6bdac12fa32018c02f572bbe367321e672fad9adc3a23aa73ff4a431b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antineoplastic Agents - pharmacology</topic><topic>Breast Neoplasms - genetics</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>DNA - metabolism</topic><topic>Female</topic><topic>Gene Dosage</topic><topic>Genes, myc</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Mucin-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Falkiewicz, B</creatorcontrib><creatorcontrib>Schlotter, C M</creatorcontrib><creatorcontrib>Bosse, U</creatorcontrib><creatorcontrib>Bielawski, K</creatorcontrib><creatorcontrib>Vogt, U</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biochimica polonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Falkiewicz, B</au><au>Schlotter, C M</au><au>Bosse, U</au><au>Bielawski, K</au><au>Vogt, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer</atitle><jtitle>Acta biochimica polonica</jtitle><addtitle>Acta Biochim Pol</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>47</volume><issue>1</issue><spage>149</spage><epage>156</epage><pages>149-156</pages><issn>0001-527X</issn><eissn>1734-154X</eissn><abstract>A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Antineoplastic Agents - pharmacology Breast Neoplasms - genetics Carcinoembryonic Antigen - blood DNA - metabolism Female Gene Dosage Genes, myc Humans In Vitro Techniques Mucin-1 - blood |
| title | c-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer |
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