Distribution of macrolide resistance genes erm(B) and mef(A) among 160 penicillin-intermediate clinical isolates of Streptococcus pneumoniae isolated in Southern France

Two prevalent mechanisms of macrolide resistance are currently described in pneumococci: production of rRNA methylase that modify 23S ribosomal RNA resulting in MLS B phenotype, and an active efflux system resulting in M-phenotype. These two mechanisms are mediated by erm(B) and mef(A) genes respect...

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Veröffentlicht in:	Pathologie biologie (Paris) 2001-09, Vol.49 (7), p.522-527
Hauptverfasser:	Marchandin, H, Jean-Pierre, H, Jumas-Bilak, E, Isson, L, Drouillard, B, Darbas, H, Carrière, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - genetics Biological and medical sciences determinants Drug Resistance - genetics Drug Resistance, Multiple - genetics Electrophoresis, Gel, Pulsed-Field Erythromycin - pharmacology Europe - epidemiology France - epidemiology Genotype gènes Humans macrolides Medical sciences Membrane Proteins - genetics Methyltransferases - genetics Microbial Sensitivity Tests PCR Penicillin Resistance Pharmacology. Drug treatments Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology resistance résistance Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification
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