Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation

Tumour hypoxia is the result of an imbalance in oxygen supply and demand. It is an adverse prognostic indicator in cancer as it modulates tumour progression and treatment. Many genes controlling tumour biology are oxygen regulated, and new ones are constantly added to the growing list of hypoxia-ind...

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Veröffentlicht in:	European journal of cancer (1990) 2000-08, Vol.36 (13), p.1649-1660
Hauptverfasser:	Dachs, G.U, Tozer, G.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Hypoxia - genetics DNA-Binding Proteins - genetics Endothelial Growth Factors - genetics Gene therapy Genes, p53 - genetics Genetic Therapy - methods Humans Hypoxia inducible factor-1 Hypoxia-Inducible Factor 1, alpha Subunit Lymphokines - genetics Matrix Metalloproteinases - physiology Neoplasm Metastasis - genetics Neoplasm Metastasis - therapy Neoplasm Proteins - genetics Neoplasms - blood supply Neoplasms - genetics Neovascularization, Pathologic Nitric oxide synthase Nitric Oxide Synthase - physiology Nuclear Proteins - genetics Transcription Factors Urokinase-Type Plasminogen Activator - physiology Vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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