RANKL Induces Formation of Avian Osteoclasts from Macrophages but Not from Macrophage Polykaryons

We have shown that chick macrophages express RANK at their surface and human RANKL (hRANKL) triggers the formation of osteoclasts able to degrade dentine. As described for mammalian osteoclasts, hRANKL also stimulates the resorbing activity of chick bone-derived osteoclasts. In other hands, in cultu...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-10, Vol.288 (2), p.340-346
Hauptverfasser:	Boissy, Patrice, Destaing, Olivier, Jurdic, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Carrier Proteins - pharmacology Chickens Dentin - metabolism Giant Cells - drug effects Giant Cells - physiology Glycoproteins - biosynthesis Glycoproteins - metabolism Humans Macrophages - drug effects Macrophages - physiology Membrane Glycoproteins - pharmacology Osteoclasts - metabolism Osteoprotegerin RANK Ligand RANKL protein Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Tumor Necrosis Factor TRANCE protein
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