Osteopontin-Deficient Bone Cells Are Defective in Their Ability to Produce NO in Response to Pulsatile Fluid Flow

Osteopontin (OPN) is a noncollagenous component of bone matrix. It mediates cell attachment and activates signal transduction pathways. In this work, bone cells, cultured from fragments of long bones derived from wild-type and OPN−/− (“knock-out”) mice, were exposed to pulsatile fluid flow (PFF) ove...

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