Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression

We report the results of a multidisciplinary study on the inhibitory effect of a snake venom disintegrin, contortrostatin, a 13.5 kDa homodimeric protein isolated from Agkistrodon contortrix contortrix (southern copperhead) venom, on breast cancer progression. We demonstrate that contortrostatin bin...

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Veröffentlicht in:	Breast cancer research and treatment 2000-06, Vol.61 (3), p.249-260
Hauptverfasser:	QING ZHOU, SHERWIN, R. P, PARRISH, C, RICHTERS, V, GROSHEN, S. G, TSAO-WEI, D, MARKLAND, F. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Agkistrodon Animals Biological and medical sciences Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - prevention & control Cancer research Cancer therapies Carcinogenesis, carcinogens and anticarcinogens Cell Adhesion - drug effects Cell Division - drug effects Crotalid Venoms - chemistry Disease Progression Disintegrins - isolation & purification Disintegrins - pharmacology Extracellular Matrix - metabolism Extracellular Matrix Proteins - metabolism Female Foods and miscellaneous Humans Lung Neoplasms - prevention & control Lung Neoplasms - secondary Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neovascularization, Pathologic - drug therapy Receptors, Vitronectin - antagonists & inhibitors Receptors, Vitronectin - metabolism Tumor Cells, Cultured Tumors
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