α-Fluorinated Phosphonates as Substrate Mimics for Glucose 6-Phosphate Dehydrogenase:  the CHF Stereochemistry Matters

Reported is a systematic study of the “fitness” (in terms of k cat/K m) of a series of phosphonate mimics of glucose 6-phosphate (G6P) as unnatural substrates for G6P dehydrogenase from Leuconostoc mesenteroides. The four G6P analogues (9, 10, 15a, and 15b) differ only in the degree of fluorination...

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