Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart

The roles of the Ca2+-mobilising messenger inositol 1,4,5-trisphosphate (InsP3) in heart are unclear, although many hormones activate InsP3 production in cardiomyocytes and some of their inotropic, chronotropic and arrhythmogenic effects may be due to Ca2+ release mediated by InsP3 receptors (InsP3R...

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Veröffentlicht in:	Current biology 2000-08, Vol.10 (15), p.939,S1-942,S1
Hauptverfasser:	Lipp, Peter, Laine, Mika, Tovey, Stephen C., Burrell, Kylie M., Berridge, Michael J., Li, Wenhong, Bootman, Martin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calcium Channels - metabolism Heart - physiology In Vitro Techniques Inositol 1,4,5-Trisphosphate Receptors Myocardial Contraction - physiology Myocardium - cytology Myocardium - metabolism Polymerase Chain Reaction Receptors, Cytoplasmic and Nuclear - metabolism Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - physiology
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