Cross-resistance to the synthetic retinoid CD437 in a paclitaxel-resistant human ovarian carcinoma cell line is independent of the overexpression of retinoic acid receptor-γ

Treatment of ovarian carcinomas with the antimitotic antitumor drug paclitaxel is highly efficacious. However, development of drug resistance presents a major obstacle. The common cellular phenotypes associated with paclitaxel resistance are an increased expression of the drug transport protein P-gl...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-10, Vol.61 (20), p.7552-7555
Hauptverfasser:	KUMAR, Atul, SOPRANO, Dianne R, PAREKH, Hemant K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Blotting, Northern Chemotherapy Drug Resistance, Multiple - genetics Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm Female Humans Medical sciences Oligonucleotide Array Sequence Analysis Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Paclitaxel - pharmacology Pharmacology. Drug treatments Receptors, Retinoic Acid - biosynthesis Receptors, Retinoic Acid - genetics Retinoic Acid Receptor gamma Retinoids - pharmacology Tumor Cells, Cultured - drug effects
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