Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF

Huntington's disease (HD) is an autosomal dominant genetic disease with devastating clinical effects on cognitive, psychological, and motor functions. These clinical symptoms primarily relate to the progressive loss of medium-spiny GABA-ergic neurons of the striatum. There is no known treatment...

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Veröffentlicht in:	Human gene therapy 2000-08, Vol.11 (12), p.1723-1729
Hauptverfasser:	BACHOUD-LEVI, A.-C, DEGLON, N, BAUDIC, S, CESARO, P, PESCHANSKI, M, AEBISCHER, P, NGUYEN, J.-P, BLOCH, J, BOURDET, C, WINKEL, L, REMY, P, GODDARD, M, LEFAUCHEUR, J.-P, BRUGIERES, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Cell Line Cerebral Ventricles - metabolism Ciliary Neurotrophic Factor - genetics Ciliary Neurotrophic Factor - metabolism Ciliary Neurotrophic Factor - secretion Clinical Protocols Clinical Trials, Phase I as Topic Cricetinae Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic Therapy Health. Pharmaceutical industry Humans Huntington Disease - therapy Industrial applications and implications. Economical aspects Patient Selection
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