Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats : relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression

Dopamine dysfunction in the nucleus accumbens is thought to underlie the altered propensity of isolation-reared rats to self-administer psychomotor stimulants. To identify specific changes in monoamine and glutamate function in the nucleus accumbens and c-fos induction in the amygdala and striatum w...

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Veröffentlicht in:	Psychopharmacologia 2000-07, Vol.151 (1), p.55-63
Hauptverfasser:	HOWES, S. R, DALLEY, J. W, MORRISON, C. H, ROBBINS, T. W, EVERITT, B. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - metabolism Analysis of Variance Anesthetics, Local - administration & dosage Animals Basal Ganglia - metabolism Biological and medical sciences Brain c-Fos protein Caudate-putamen Cocaine Cocaine - administration & dosage Dopamine Dopamine - metabolism Drug addictions Drug self-administration Extracellular levels Glutamic Acid - metabolism Immunocytochemistry Immunohistochemistry Male Medical sciences Microdialysis Neostriatum Nucleus accumbens Nucleus Accumbens - metabolism Oncogene Proteins v-fos - analysis Oncogene Proteins v-fos - biosynthesis Psychomotor stimulants Rats Self Administration - psychology Serotonin Serotonin - metabolism Social Isolation Stimulants Toxicology
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