HNF-1 regulates the liver-specific transcription of the chipmunk HP-20 gene

The chipmunk hibernation-specific protein HP-20 is a component of the 140 kDa complex that drastically decreases in the blood during hibernation, and its gene is expressed specifically in the liver. To reveal molecular mechanisms underlying the liver-specific transcription of the HP-20 gene, we isol...

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Veröffentlicht in:	Gene 2001-10, Vol.277 (1), p.121-127
Hauptverfasser:	Ono, Motoharu, Hosoe, Yuko, Azuma, Sakura, Shoji, Minami, Nara, Keiko, Kondo, Noriaki, Shiba, Tadayoshi, Takamatsu, Nobuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Amino Acid Sequence Animals Base Sequence Binding Sites - genetics Blood Proteins - genetics COS Cells DNA - chemistry DNA - genetics DNA-Binding Proteins Gene Expression Regulation Gene organization Genes - genetics Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta Hibernation HP-20 protein Humans Liver - metabolism Luciferase assay Luciferases - genetics Luciferases - metabolism Molecular Sequence Data Mutation Nuclear Proteins Oligonucleotides - genetics Oligonucleotides - metabolism Promoter Promoter Regions, Genetic - genetics Protein Binding Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sciuridae - genetics Sequence Analysis, DNA Sequence Deletion Tamias Transcription factor Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic Tumor Cells, Cultured
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