Determination of dexamethasone and two excipients (creatinine and propylparaben) in injections by using UV-spectroscopy and multivariate calibrations

The use of multivariate spectrophotometric calibration for the simultaneous determination of dexamethasone and two typical excipients (creatinine and propylparaben) in injections is presented. The resolution of the three-component mixture in a matrix of excipients has been accomplished by using part...

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Veröffentlicht in:	International journal of pharmaceutics 2001-10, Vol.229 (1), p.205-211
Hauptverfasser:	Collado, Marı́a S., Robles, Juan C., De Zan, Mercedes, Cámara, Marı́a S., Mantovani, Vı́ctor E., Goicoechea, Héctor C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Calibration Chromatography, High Pressure Liquid Creatinine Creatinine - analysis Dexamethasone Dexamethasone - analysis General pharmacology Indicators and Reagents Medical sciences Multivariate Analysis Multivariate calibration Parabens - analysis Pharmacology. Drug treatments Propylparaben Reproducibility of Results Spectrophotometry Spectrophotometry, Ultraviolet
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