Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: Involvement of mitogen-activated protein kinase and Fas pathways

Prospective studies and recent intervention trials suggest that the risk of some cancers, including respiratory tract cancers, may be inversely related to selenium (SE) intake, and this is supported by strong experimental evidence with chemical-induced animal cancer models. How this cancer-protectiv...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-10, Vol.61 (20), p.7479-7487
Hauptverfasser:	GHOSE, Aurnab, FLEMING, Janis, EL-BAYOUMY, Karam, HARRISON, Paul R
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Chemical agents Enzyme Induction - drug effects Fas Ligand Protein Glutathione - analogs & derivatives Glutathione - pharmacology Growth Inhibitors - pharmacology HeLa Cells Humans MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - physiology Mice Mitogen-Activated Protein Kinases - biosynthesis Mitogen-Activated Protein Kinases - metabolism Mouth Mucosa - cytology Mouth Mucosa - drug effects Mouth Neoplasms - drug therapy Mouth Neoplasms - pathology Organoselenium Compounds - pharmacology Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Signal Transduction - drug effects Tumors
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