Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy
Transplant vasculopathy is the main limiting factor of the long-term success of heart transplantation. We sought to establish the role of platelets in the development and progression of transplant vasculopathy. Platelet analysis and intracoronary ultrasound examination were performed in 78 heart tra...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2000-08, Vol.102 (8), p.890-897 |
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| creator | FATEH-MOGHADAM, Suzanne BOCKSCH, Wolfgang RUF, Andreas DICKFELD, Timm SCHARTL, Michael POGATSA-MURRAY, Gisela HETZER, Roland FLECK, Eckart GAWAZ, Meinrad |
| description | Transplant vasculopathy is the main limiting factor of the long-term success of heart transplantation. We sought to establish the role of platelets in the development and progression of transplant vasculopathy.
Platelet analysis and intracoronary ultrasound examination were performed in 78 heart transplant recipients. Quantitative intracoronary ultrasound was used to define the severity of disease at baseline (48.8+/-4.5 months after transplantation) and at 1-year follow-up. Platelet activation was assessed with the use of immunological surface markers of activation (ligand-induced binding site 1 [LIBS-1], P-selectin, GPIIb-IIIa) and flow cytometry. We found that LIBS-1 immunoreactivity was significantly increased in patients with diffuse disease when compared with focal transplant disease (median [quartile], 27[14, 64] versus 18[7.9, 47], P=0.04). In a logistic regression model, we found that LIBS-1 was an independent predictor for the presence and progression of diffuse transplant vasculopathy (P=0.04). Patients with enhanced LIBS-1 levels (>75% quartile) had a 3.3-fold increased relative risk (95% CI 1.8 and 18.9, P=0.002) for the presence of diffuse transplant vasculopathy. When a cutoff value of 16.5 for the level of LIBS-1 was used, patients had a 4.8-fold increased relative risk (95% CI 1.9 and 12.5, P |
| doi_str_mv | 10.1161/01.CIR.102.8.890 |
| format | Article |
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Platelet analysis and intracoronary ultrasound examination were performed in 78 heart transplant recipients. Quantitative intracoronary ultrasound was used to define the severity of disease at baseline (48.8+/-4.5 months after transplantation) and at 1-year follow-up. Platelet activation was assessed with the use of immunological surface markers of activation (ligand-induced binding site 1 [LIBS-1], P-selectin, GPIIb-IIIa) and flow cytometry. We found that LIBS-1 immunoreactivity was significantly increased in patients with diffuse disease when compared with focal transplant disease (median [quartile], 27[14, 64] versus 18[7.9, 47], P=0.04). In a logistic regression model, we found that LIBS-1 was an independent predictor for the presence and progression of diffuse transplant vasculopathy (P=0.04). Patients with enhanced LIBS-1 levels (>75% quartile) had a 3.3-fold increased relative risk (95% CI 1.8 and 18.9, P=0.002) for the presence of diffuse transplant vasculopathy. When a cutoff value of 16.5 for the level of LIBS-1 was used, patients had a 4.8-fold increased relative risk (95% CI 1.9 and 12.5, P<0.01) for the progression of transplant vasculopathy.
Enhanced platelet activation is strongly associated with the development and progression of transplant vasculopathy. Understanding the underlying pathophysiological mechanisms might contribute to the development of treatment strategies to prevent transplant vasculopathy.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.102.8.890</identifier><identifier>PMID: 10952958</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Blood Platelets - immunology ; Blood Platelets - metabolism ; Coronary Disease - blood ; Coronary Disease - etiology ; Coronary Disease - immunology ; Disease Progression ; Female ; Heart Transplantation - adverse effects ; Heart Transplantation - immunology ; Humans ; Male ; Medical sciences ; Middle Aged ; Platelet Activation - immunology ; Platelet Glycoprotein GPIIb-IIIa Complex - biosynthesis ; Platelet Glycoprotein GPIIb-IIIa Complex - immunology ; Platelet Glycoprotein GPIIb-IIIa Complex - metabolism ; Platelet Membrane Glycoproteins - biosynthesis ; Platelet Membrane Glycoproteins - immunology ; Platelet Membrane Glycoproteins - metabolism ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart</subject><ispartof>Circulation (New York, N.Y.), 2000-08, Vol.102 (8), p.890-897</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Aug 22, 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-59c4f0ca71caf7aac98aa4c6ae1bf9d89305ad5319e693ea7ca7f4d341b063d13</citedby><cites>FETCH-LOGICAL-c434t-59c4f0ca71caf7aac98aa4c6ae1bf9d89305ad5319e693ea7ca7f4d341b063d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1531461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10952958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FATEH-MOGHADAM, Suzanne</creatorcontrib><creatorcontrib>BOCKSCH, Wolfgang</creatorcontrib><creatorcontrib>RUF, Andreas</creatorcontrib><creatorcontrib>DICKFELD, Timm</creatorcontrib><creatorcontrib>SCHARTL, Michael</creatorcontrib><creatorcontrib>POGATSA-MURRAY, Gisela</creatorcontrib><creatorcontrib>HETZER, Roland</creatorcontrib><creatorcontrib>FLECK, Eckart</creatorcontrib><creatorcontrib>GAWAZ, Meinrad</creatorcontrib><title>Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Transplant vasculopathy is the main limiting factor of the long-term success of heart transplantation. We sought to establish the role of platelets in the development and progression of transplant vasculopathy.
Platelet analysis and intracoronary ultrasound examination were performed in 78 heart transplant recipients. Quantitative intracoronary ultrasound was used to define the severity of disease at baseline (48.8+/-4.5 months after transplantation) and at 1-year follow-up. Platelet activation was assessed with the use of immunological surface markers of activation (ligand-induced binding site 1 [LIBS-1], P-selectin, GPIIb-IIIa) and flow cytometry. We found that LIBS-1 immunoreactivity was significantly increased in patients with diffuse disease when compared with focal transplant disease (median [quartile], 27[14, 64] versus 18[7.9, 47], P=0.04). In a logistic regression model, we found that LIBS-1 was an independent predictor for the presence and progression of diffuse transplant vasculopathy (P=0.04). Patients with enhanced LIBS-1 levels (>75% quartile) had a 3.3-fold increased relative risk (95% CI 1.8 and 18.9, P=0.002) for the presence of diffuse transplant vasculopathy. When a cutoff value of 16.5 for the level of LIBS-1 was used, patients had a 4.8-fold increased relative risk (95% CI 1.9 and 12.5, P<0.01) for the progression of transplant vasculopathy.
Enhanced platelet activation is strongly associated with the development and progression of transplant vasculopathy. Understanding the underlying pathophysiological mechanisms might contribute to the development of treatment strategies to prevent transplant vasculopathy.</description><subject>Biological and medical sciences</subject><subject>Blood Platelets - immunology</subject><subject>Blood Platelets - metabolism</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - etiology</subject><subject>Coronary Disease - immunology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Heart Transplantation - adverse effects</subject><subject>Heart Transplantation - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Platelet Activation - immunology</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - biosynthesis</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - immunology</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - metabolism</subject><subject>Platelet Membrane Glycoproteins - biosynthesis</subject><subject>Platelet Membrane Glycoproteins - immunology</subject><subject>Platelet Membrane Glycoproteins - metabolism</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1rFEEQxRtRzCZ69ySNBG8z9ufM9FEWo4GAEPTc1PbU7E6Yr3T3BPe_T8kuGDwVD36vqHqPsQ9SlFJW8ouQ5fb2vpRClU3ZOPGKbaRVpjBWu9dsI4RwRa2VumCXKT2QrHRt37ILKZxVzjYb9rg9wLTHxPuJpzV2EJDjnyViSv088bnjywAZB8x8xHEXYUK-H45hXuKcsZ8Sh6nlJPYvLAeEmHkmOJF7yvwJUliHeYF8OL5jbzoYEr4_zyv2--bbr-2P4u7n99vt17siGG1yYV0wnQhQywBdDRBcA2BCBSh3nWsbp4WF1mrpsHIaoSa0M602ckdftlJfsc-nvXTc44op-7FPAQc6COc1-VopoStbEfjpP_BhXuNEt3klVW0MpUiQOEEhzilF7PwS-xHi0Uvh_3bhhfTUBUnlG09dkOXjee-6G7F9YTiFT8D1GaB4YOgor9Cnfxw9ZyqpnwH4x5RB</recordid><startdate>20000822</startdate><enddate>20000822</enddate><creator>FATEH-MOGHADAM, Suzanne</creator><creator>BOCKSCH, Wolfgang</creator><creator>RUF, Andreas</creator><creator>DICKFELD, Timm</creator><creator>SCHARTL, Michael</creator><creator>POGATSA-MURRAY, Gisela</creator><creator>HETZER, Roland</creator><creator>FLECK, Eckart</creator><creator>GAWAZ, Meinrad</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20000822</creationdate><title>Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy</title><author>FATEH-MOGHADAM, Suzanne ; BOCKSCH, Wolfgang ; RUF, Andreas ; DICKFELD, Timm ; SCHARTL, Michael ; POGATSA-MURRAY, Gisela ; HETZER, Roland ; FLECK, Eckart ; GAWAZ, Meinrad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-59c4f0ca71caf7aac98aa4c6ae1bf9d89305ad5319e693ea7ca7f4d341b063d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Blood Platelets - immunology</topic><topic>Blood Platelets - metabolism</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - etiology</topic><topic>Coronary Disease - immunology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Heart Transplantation - adverse effects</topic><topic>Heart Transplantation - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Platelet Activation - immunology</topic><topic>Platelet Glycoprotein GPIIb-IIIa Complex - biosynthesis</topic><topic>Platelet Glycoprotein GPIIb-IIIa Complex - immunology</topic><topic>Platelet Glycoprotein GPIIb-IIIa Complex - metabolism</topic><topic>Platelet Membrane Glycoproteins - biosynthesis</topic><topic>Platelet Membrane Glycoproteins - immunology</topic><topic>Platelet Membrane Glycoproteins - metabolism</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FATEH-MOGHADAM, Suzanne</creatorcontrib><creatorcontrib>BOCKSCH, Wolfgang</creatorcontrib><creatorcontrib>RUF, Andreas</creatorcontrib><creatorcontrib>DICKFELD, Timm</creatorcontrib><creatorcontrib>SCHARTL, Michael</creatorcontrib><creatorcontrib>POGATSA-MURRAY, Gisela</creatorcontrib><creatorcontrib>HETZER, Roland</creatorcontrib><creatorcontrib>FLECK, Eckart</creatorcontrib><creatorcontrib>GAWAZ, Meinrad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FATEH-MOGHADAM, Suzanne</au><au>BOCKSCH, Wolfgang</au><au>RUF, Andreas</au><au>DICKFELD, Timm</au><au>SCHARTL, Michael</au><au>POGATSA-MURRAY, Gisela</au><au>HETZER, Roland</au><au>FLECK, Eckart</au><au>GAWAZ, Meinrad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2000-08-22</date><risdate>2000</risdate><volume>102</volume><issue>8</issue><spage>890</spage><epage>897</epage><pages>890-897</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Transplant vasculopathy is the main limiting factor of the long-term success of heart transplantation. We sought to establish the role of platelets in the development and progression of transplant vasculopathy.
Platelet analysis and intracoronary ultrasound examination were performed in 78 heart transplant recipients. Quantitative intracoronary ultrasound was used to define the severity of disease at baseline (48.8+/-4.5 months after transplantation) and at 1-year follow-up. Platelet activation was assessed with the use of immunological surface markers of activation (ligand-induced binding site 1 [LIBS-1], P-selectin, GPIIb-IIIa) and flow cytometry. We found that LIBS-1 immunoreactivity was significantly increased in patients with diffuse disease when compared with focal transplant disease (median [quartile], 27[14, 64] versus 18[7.9, 47], P=0.04). In a logistic regression model, we found that LIBS-1 was an independent predictor for the presence and progression of diffuse transplant vasculopathy (P=0.04). Patients with enhanced LIBS-1 levels (>75% quartile) had a 3.3-fold increased relative risk (95% CI 1.8 and 18.9, P=0.002) for the presence of diffuse transplant vasculopathy. When a cutoff value of 16.5 for the level of LIBS-1 was used, patients had a 4.8-fold increased relative risk (95% CI 1.9 and 12.5, P<0.01) for the progression of transplant vasculopathy.
Enhanced platelet activation is strongly associated with the development and progression of transplant vasculopathy. Understanding the underlying pathophysiological mechanisms might contribute to the development of treatment strategies to prevent transplant vasculopathy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10952958</pmid><doi>10.1161/01.CIR.102.8.890</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation (New York, N.Y.), 2000-08, Vol.102 (8), p.890-897 |
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| source | MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Biological and medical sciences Blood Platelets - immunology Blood Platelets - metabolism Coronary Disease - blood Coronary Disease - etiology Coronary Disease - immunology Disease Progression Female Heart Transplantation - adverse effects Heart Transplantation - immunology Humans Male Medical sciences Middle Aged Platelet Activation - immunology Platelet Glycoprotein GPIIb-IIIa Complex - biosynthesis Platelet Glycoprotein GPIIb-IIIa Complex - immunology Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Platelet Membrane Glycoproteins - biosynthesis Platelet Membrane Glycoproteins - immunology Platelet Membrane Glycoproteins - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart |
| title | Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy |
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