Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli: Important Role of Nitric Oxide

ABSTRACT—Advanced aging leads to impaired endothelial NO synthesis and enhanced endothelial cell apoptosis; therefore, we investigated the sensitivity of aged endothelial cells toward apoptotic stimuli and determined the role of NO. Human umbilical vein endothelial cells (HUVECs) were cultured until...

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Veröffentlicht in:	Circulation research 2001-10, Vol.89 (8), p.709-715
Hauptverfasser:	Hoffmann, Jörg, Haendeler, Judith, Aicher, Alexandra, Rössig, Lothar, Vasa, Mariuca, Zeiher, Andreas M, Dimmeler, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Aging - drug effects Aging - metabolism Amino Acid Substitution Animals Aorta Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Caspase 3 Caspases - metabolism Cell physiology Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Enzyme Activation - genetics Fundamental and applied biological sciences. Psychology Humans Lipoproteins, LDL - pharmacology Male Mice Mice, Knockout Molecular and cellular biology Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - deficiency Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Nitroso Compounds - metabolism Phosphorylation Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Stress, Mechanical Sulfhydryl Compounds - metabolism Transfection Tumor Necrosis Factor-alpha - pharmacology
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