Testosterone Facilitates the Baroreceptor Control of Reflex Bradycardia: Role of Cardiac Sympathetic and Parasympathetic Components
Reported clinical and experimental findings have shown that baroreflex control of heart rate is attenuated in women compared with men. This study investigated whether the sexual dimorphism in baroreflex function relates to the ability of the male hormone testosterone to facilitate baroreflex respons...
Gespeichert in:
| Veröffentlicht in: | Journal of cardiovascular pharmacology 2001-11, Vol.38 (5), p.754-763 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 763 |
|---|---|
| container_issue | 5 |
| container_start_page | 754 |
| container_title | Journal of cardiovascular pharmacology |
| container_volume | 38 |
| creator | El-Mas, Mahmoud M Afify, Elham A Mohy El-Din, Mahmoud M Omar, Amal G Sharabi, Fouad M |
| description | Reported clinical and experimental findings have shown that baroreflex control of heart rate is attenuated in women compared with men. This study investigated whether the sexual dimorphism in baroreflex function relates to the ability of the male hormone testosterone to facilitate baroreflex responsiveness. Relative contributions of the vagal and sympathetic autonomic components to testosterone modulation of baroreflex function were also investigated. Baroreflex curves relating changes in heart rate to increases or decreases in blood pressure evoked by phenylephrine and sodium nitroprusside, respectively, were constructed in sham-operated rats and castrated rats with and without testosterone replacement. Slope of the curves was taken as an index of baroreflex sensitivity (BRS PE and BRS NP ). Castration (for 10 days) significantly reduced plasma testosterone levels and attenuated reflex bradycardia, as indicated by significantly smaller BRS PE in castrated rats compared with values in sham-operated rats (−0.85 ± 0.07 vs. −1.51 ± 0.10 beats/min per mm Hg). Testosterone replacement in castrated rats restored plasma testosterone and BRS PE to levels similar to those of sham-operated rats. Muscarinic blockade by atropine caused 55% reduction in BRS PE in sham-operated rats, an effect that was significantly (p < 0.05) attenuated in castrated rats and restored to intact levels after testosterone supplementation. β-Adrenergic blockade by propranolol caused slight and insignificant decreases in BRS PE . Castration and testosterone supplementation had no effect on BRS NP , ruling out a modulatory effect of testosterone on reflex tachycardia. These data provide the first experimental evidence of a favorable role for testosterone in baroreceptor control of reflex bradycardia. Further, baroreflex modulation by testosterone appears to be autonomically mediated and involves an enhancement of cardiomotor vagal activity. |
| doi_str_mv | 10.1097/00005344-200111000-00012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72202304</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72202304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5022-e6c9d2e525741e771d7f4b50ee88dc2fede0c1a1da72938f8cb66d0b239af9443</originalsourceid><addsrcrecordid>eNp1ksFu1DAQhi0EokvhFZAvcAvYjhMn3GhEAakSVSlna9YeawNOHGyvyp558Xq7C-2llkbWeL6ZkecfQihn7zjr1XtWTlNLWQnGOOfFq4px8YSseFPXlWSifkpWjLesElK2J-RFSj8LIRvVPicnvAREJ8SK_L3GlEPKGMOM9BzM6McMGRPNG6RnEENEg0sOkQ5hzjF4Ghy9QufxDz2LYHcGoh3hA70KHvex4c439PtuWqAUyaOhMFt6CRHSg7chTEvpOef0kjxz4BO-Ot6n5Mf5p-vhS3Xx7fPX4eNFZRomRIWt6a3ARjRKclSKW-XkumGIXWeNcGiRGQ7cghJ93bnOrNvWsrWoe3C9lPUpeXuou8Twe1v-racxGfQeZgzbpJUQZW5sD3YH0MSQUkSnlzhOEHeaM70XQP8TQP8XQN8JUFJfH3ts1xPa-8TjxAvw5ghAMuBdhNmM6Z6TrO1V0xdOHrib4Is66Zff3mDUGwSfN_qxBahvASISn3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72202304</pqid></control><display><type>article</type><title>Testosterone Facilitates the Baroreceptor Control of Reflex Bradycardia: Role of Cardiac Sympathetic and Parasympathetic Components</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>El-Mas, Mahmoud M ; Afify, Elham A ; Mohy El-Din, Mahmoud M ; Omar, Amal G ; Sharabi, Fouad M</creator><creatorcontrib>El-Mas, Mahmoud M ; Afify, Elham A ; Mohy El-Din, Mahmoud M ; Omar, Amal G ; Sharabi, Fouad M</creatorcontrib><description>Reported clinical and experimental findings have shown that baroreflex control of heart rate is attenuated in women compared with men. This study investigated whether the sexual dimorphism in baroreflex function relates to the ability of the male hormone testosterone to facilitate baroreflex responsiveness. Relative contributions of the vagal and sympathetic autonomic components to testosterone modulation of baroreflex function were also investigated. Baroreflex curves relating changes in heart rate to increases or decreases in blood pressure evoked by phenylephrine and sodium nitroprusside, respectively, were constructed in sham-operated rats and castrated rats with and without testosterone replacement. Slope of the curves was taken as an index of baroreflex sensitivity (BRS PE and BRS NP ). Castration (for 10 days) significantly reduced plasma testosterone levels and attenuated reflex bradycardia, as indicated by significantly smaller BRS PE in castrated rats compared with values in sham-operated rats (−0.85 ± 0.07 vs. −1.51 ± 0.10 beats/min per mm Hg). Testosterone replacement in castrated rats restored plasma testosterone and BRS PE to levels similar to those of sham-operated rats. Muscarinic blockade by atropine caused 55% reduction in BRS PE in sham-operated rats, an effect that was significantly (p < 0.05) attenuated in castrated rats and restored to intact levels after testosterone supplementation. β-Adrenergic blockade by propranolol caused slight and insignificant decreases in BRS PE . Castration and testosterone supplementation had no effect on BRS NP , ruling out a modulatory effect of testosterone on reflex tachycardia. These data provide the first experimental evidence of a favorable role for testosterone in baroreceptor control of reflex bradycardia. Further, baroreflex modulation by testosterone appears to be autonomically mediated and involves an enhancement of cardiomotor vagal activity.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-200111000-00012</identifier><identifier>PMID: 11602822</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Animals ; Atropine - pharmacology ; Autonomic Nervous System - drug effects ; Baroreflex - drug effects ; Baroreflex - physiology ; Biological and medical sciences ; Blood Pressure - drug effects ; Bradycardia - etiology ; Castration ; Heart - innervation ; Heart Rate - drug effects ; Hormones. Endocrine system ; Male ; Medical sciences ; Muscarinic Antagonists - pharmacology ; Nitroprusside - pharmacology ; Pharmacology. Drug treatments ; Phenylephrine - pharmacology ; Pressoreceptors - drug effects ; Pressoreceptors - physiology ; Propranolol - pharmacology ; Rats ; Testosterone - pharmacology</subject><ispartof>Journal of cardiovascular pharmacology, 2001-11, Vol.38 (5), p.754-763</ispartof><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5022-e6c9d2e525741e771d7f4b50ee88dc2fede0c1a1da72938f8cb66d0b239af9443</citedby><cites>FETCH-LOGICAL-c5022-e6c9d2e525741e771d7f4b50ee88dc2fede0c1a1da72938f8cb66d0b239af9443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00005344-200111000-00012$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-200111000-00012$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14069759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11602822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Mas, Mahmoud M</creatorcontrib><creatorcontrib>Afify, Elham A</creatorcontrib><creatorcontrib>Mohy El-Din, Mahmoud M</creatorcontrib><creatorcontrib>Omar, Amal G</creatorcontrib><creatorcontrib>Sharabi, Fouad M</creatorcontrib><title>Testosterone Facilitates the Baroreceptor Control of Reflex Bradycardia: Role of Cardiac Sympathetic and Parasympathetic Components</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Reported clinical and experimental findings have shown that baroreflex control of heart rate is attenuated in women compared with men. This study investigated whether the sexual dimorphism in baroreflex function relates to the ability of the male hormone testosterone to facilitate baroreflex responsiveness. Relative contributions of the vagal and sympathetic autonomic components to testosterone modulation of baroreflex function were also investigated. Baroreflex curves relating changes in heart rate to increases or decreases in blood pressure evoked by phenylephrine and sodium nitroprusside, respectively, were constructed in sham-operated rats and castrated rats with and without testosterone replacement. Slope of the curves was taken as an index of baroreflex sensitivity (BRS PE and BRS NP ). Castration (for 10 days) significantly reduced plasma testosterone levels and attenuated reflex bradycardia, as indicated by significantly smaller BRS PE in castrated rats compared with values in sham-operated rats (−0.85 ± 0.07 vs. −1.51 ± 0.10 beats/min per mm Hg). Testosterone replacement in castrated rats restored plasma testosterone and BRS PE to levels similar to those of sham-operated rats. Muscarinic blockade by atropine caused 55% reduction in BRS PE in sham-operated rats, an effect that was significantly (p < 0.05) attenuated in castrated rats and restored to intact levels after testosterone supplementation. β-Adrenergic blockade by propranolol caused slight and insignificant decreases in BRS PE . Castration and testosterone supplementation had no effect on BRS NP , ruling out a modulatory effect of testosterone on reflex tachycardia. These data provide the first experimental evidence of a favorable role for testosterone in baroreceptor control of reflex bradycardia. Further, baroreflex modulation by testosterone appears to be autonomically mediated and involves an enhancement of cardiomotor vagal activity.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Baroreflex - drug effects</subject><subject>Baroreflex - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Bradycardia - etiology</subject><subject>Castration</subject><subject>Heart - innervation</subject><subject>Heart Rate - drug effects</subject><subject>Hormones. Endocrine system</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Nitroprusside - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylephrine - pharmacology</subject><subject>Pressoreceptors - drug effects</subject><subject>Pressoreceptors - physiology</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Testosterone - pharmacology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ksFu1DAQhi0EokvhFZAvcAvYjhMn3GhEAakSVSlna9YeawNOHGyvyp558Xq7C-2llkbWeL6ZkecfQihn7zjr1XtWTlNLWQnGOOfFq4px8YSseFPXlWSifkpWjLesElK2J-RFSj8LIRvVPicnvAREJ8SK_L3GlEPKGMOM9BzM6McMGRPNG6RnEENEg0sOkQ5hzjF4Ghy9QufxDz2LYHcGoh3hA70KHvex4c439PtuWqAUyaOhMFt6CRHSg7chTEvpOef0kjxz4BO-Ot6n5Mf5p-vhS3Xx7fPX4eNFZRomRIWt6a3ARjRKclSKW-XkumGIXWeNcGiRGQ7cghJ93bnOrNvWsrWoe3C9lPUpeXuou8Twe1v-racxGfQeZgzbpJUQZW5sD3YH0MSQUkSnlzhOEHeaM70XQP8TQP8XQN8JUFJfH3ts1xPa-8TjxAvw5ghAMuBdhNmM6Z6TrO1V0xdOHrib4Is66Zff3mDUGwSfN_qxBahvASISn3A</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>El-Mas, Mahmoud M</creator><creator>Afify, Elham A</creator><creator>Mohy El-Din, Mahmoud M</creator><creator>Omar, Amal G</creator><creator>Sharabi, Fouad M</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Testosterone Facilitates the Baroreceptor Control of Reflex Bradycardia: Role of Cardiac Sympathetic and Parasympathetic Components</title><author>El-Mas, Mahmoud M ; Afify, Elham A ; Mohy El-Din, Mahmoud M ; Omar, Amal G ; Sharabi, Fouad M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5022-e6c9d2e525741e771d7f4b50ee88dc2fede0c1a1da72938f8cb66d0b239af9443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Autonomic Nervous System - drug effects</topic><topic>Baroreflex - drug effects</topic><topic>Baroreflex - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Bradycardia - etiology</topic><topic>Castration</topic><topic>Heart - innervation</topic><topic>Heart Rate - drug effects</topic><topic>Hormones. Endocrine system</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Nitroprusside - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylephrine - pharmacology</topic><topic>Pressoreceptors - drug effects</topic><topic>Pressoreceptors - physiology</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Testosterone - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Mas, Mahmoud M</creatorcontrib><creatorcontrib>Afify, Elham A</creatorcontrib><creatorcontrib>Mohy El-Din, Mahmoud M</creatorcontrib><creatorcontrib>Omar, Amal G</creatorcontrib><creatorcontrib>Sharabi, Fouad M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Mas, Mahmoud M</au><au>Afify, Elham A</au><au>Mohy El-Din, Mahmoud M</au><au>Omar, Amal G</au><au>Sharabi, Fouad M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testosterone Facilitates the Baroreceptor Control of Reflex Bradycardia: Role of Cardiac Sympathetic and Parasympathetic Components</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>2001-11</date><risdate>2001</risdate><volume>38</volume><issue>5</issue><spage>754</spage><epage>763</epage><pages>754-763</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>Reported clinical and experimental findings have shown that baroreflex control of heart rate is attenuated in women compared with men. This study investigated whether the sexual dimorphism in baroreflex function relates to the ability of the male hormone testosterone to facilitate baroreflex responsiveness. Relative contributions of the vagal and sympathetic autonomic components to testosterone modulation of baroreflex function were also investigated. Baroreflex curves relating changes in heart rate to increases or decreases in blood pressure evoked by phenylephrine and sodium nitroprusside, respectively, were constructed in sham-operated rats and castrated rats with and without testosterone replacement. Slope of the curves was taken as an index of baroreflex sensitivity (BRS PE and BRS NP ). Castration (for 10 days) significantly reduced plasma testosterone levels and attenuated reflex bradycardia, as indicated by significantly smaller BRS PE in castrated rats compared with values in sham-operated rats (−0.85 ± 0.07 vs. −1.51 ± 0.10 beats/min per mm Hg). Testosterone replacement in castrated rats restored plasma testosterone and BRS PE to levels similar to those of sham-operated rats. Muscarinic blockade by atropine caused 55% reduction in BRS PE in sham-operated rats, an effect that was significantly (p < 0.05) attenuated in castrated rats and restored to intact levels after testosterone supplementation. β-Adrenergic blockade by propranolol caused slight and insignificant decreases in BRS PE . Castration and testosterone supplementation had no effect on BRS NP , ruling out a modulatory effect of testosterone on reflex tachycardia. These data provide the first experimental evidence of a favorable role for testosterone in baroreceptor control of reflex bradycardia. Further, baroreflex modulation by testosterone appears to be autonomically mediated and involves an enhancement of cardiomotor vagal activity.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11602822</pmid><doi>10.1097/00005344-200111000-00012</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-2446 |
| ispartof | Journal of cardiovascular pharmacology, 2001-11, Vol.38 (5), p.754-763 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72202304 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenergic beta-Antagonists - pharmacology Animals Atropine - pharmacology Autonomic Nervous System - drug effects Baroreflex - drug effects Baroreflex - physiology Biological and medical sciences Blood Pressure - drug effects Bradycardia - etiology Castration Heart - innervation Heart Rate - drug effects Hormones. Endocrine system Male Medical sciences Muscarinic Antagonists - pharmacology Nitroprusside - pharmacology Pharmacology. Drug treatments Phenylephrine - pharmacology Pressoreceptors - drug effects Pressoreceptors - physiology Propranolol - pharmacology Rats Testosterone - pharmacology |
| title | Testosterone Facilitates the Baroreceptor Control of Reflex Bradycardia: Role of Cardiac Sympathetic and Parasympathetic Components |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T18%3A38%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Testosterone%20Facilitates%20the%20Baroreceptor%20Control%20of%20Reflex%20Bradycardia:%20Role%20of%20Cardiac%20Sympathetic%20and%20Parasympathetic%20Components&rft.jtitle=Journal%20of%20cardiovascular%20pharmacology&rft.au=El-Mas,%20Mahmoud%20M&rft.date=2001-11&rft.volume=38&rft.issue=5&rft.spage=754&rft.epage=763&rft.pages=754-763&rft.issn=0160-2446&rft.eissn=1533-4023&rft.coden=JCPCDT&rft_id=info:doi/10.1097/00005344-200111000-00012&rft_dat=%3Cproquest_cross%3E72202304%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72202304&rft_id=info:pmid/11602822&rfr_iscdi=true |