Expression of a Retinoid-inducible Tumor Suppressor, Tazarotene-inducible Gene-3, Is Decreased in Psoriasis and Skin Cancer

Tazarotene-induced gene-3 ( TIG-3 ), isolated from human keratinocytes treated with the retinoic acid receptor-selective retinoid Tazarotene, is homologous to H-rev, a class II tumor suppressor. TIG-3 gene localized to chromosome 11q23, a site of loss of heterozygosity in several malignancies. Retin...

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Veröffentlicht in:	Clinical cancer research 2000-08, Vol.6 (8), p.3249-3259
Hauptverfasser:	DUVIC, M, HELEKAR, B, YOUNG, J, CLAYMAN, G, LIPPMAN, S. M, CHANDRARATNA, R. A. S, ROBINSON, N. A, DEUCHER, A, ECKERT, R. L, NAGPAL, S, SCHULZ, C, MIMI CHO, DISEPIO, D, HAGER, C, DIMAO, D, HAZARIKA, P, JACKSON, B, BREUER-MCHAM, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carrier Proteins - biosynthesis Carrier Proteins - genetics Dermatology Epidermis - metabolism Epidermis - physiology Female Gene Expression Gene Expression Profiling Genes, Tumor Suppressor Humans In Situ Hybridization Male Medical sciences Middle Aged Psoriasis - genetics Psoriasis - metabolism Psoriasis. Parapsoriasis. Lichen Receptors, Retinoic Acid Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Messenger - metabolism Skin - metabolism Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Physiological Phenomena Tumors of the skin and soft tissue. Premalignant lesions
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