Stabilization of vinca alkaloids encapsulated in poly(lactide-co-glycolide) microspheres

The purpose of this study was to stabilize the vinca alkaloids, vincristine sulfate (VCR) and vinblastine sulfate (VBL), in poly(lactide-co-glycolide) (PLGA) microspheres and to release the drugs in a sustained manner for more than a month. An oil-in-oil emulsion-solvent extraction method was used t...

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Veröffentlicht in:	Pharmaceutical research 2000-06, Vol.17 (6), p.677-683
Hauptverfasser:	MARININA, J, SHENDEROVA, A, MALLERY, S. R, SCHWENDEMAN, S. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Aqueous solutions Biological and medical sciences Chemotherapy Drug Carriers Drugs General aspects General pharmacology Kaposis sarcoma Lactic Acid - chemistry Medical sciences Microclimate Microscopy, Electron, Scanning Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polymers Polymers - chemistry Toxicity Transplants & implants Vinblastine - chemistry Vinblastine - pharmacokinetics Vincristine - chemistry Vincristine - pharmacokinetics
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