Oncolytic Herpes Simplex Virus-1 Lacking ICP34.5 Induces p53-independent Death and Is Efficacious against Chemotherapy-resistant Ovarian Cancer

Replication-restricted herpes simplex virus-1 (HSV-1) strains lacking ICP34.5 are emerging as powerful anticancer agents against several solid tumors including epithelial ovarian cancer (EOC). Although chemotherapy-resistant tumors would be likely candidates for treatment with HSV-1 mutants lacking...

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Veröffentlicht in:	Clinical cancer research 2000-08, Vol.6 (8), p.3342-3353
Hauptverfasser:	COUKOS, G, MAKRIGIANNAKIS, A, KANG, E. H, RUBIN, S. C, ALBELDA, S. M, MOLNAR-KIMBER, K. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - physiology bcl-2-Associated X Protein Biological and medical sciences Cell Death - physiology Cisplatin - pharmacology Drug Resistance, Neoplasm Female Female genital diseases Gynecology. Andrology. Obstetrics Herpesvirus 1, Human - genetics Herpesvirus 1, Human - metabolism Herpesvirus 1, Human - physiology Humans Medical sciences Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Ovarian Neoplasms - virology Paclitaxel - pharmacology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology Tumors Viral Proteins - genetics Viral Proteins - physiology Virus Replication
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