MSH2 Mutation Carriers Are at Higher Risk of Cancer Than MLH1 Mutation Carriers: A Study of Hereditary Nonpolyposis Colorectal Cancer Families

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by the clustering of colorectal cancer, endometrial cancer, and various other cancers. The disease is caused by mutations in DNA-mismatch-repair (MMR) genes, most frequently in MLH1, MSH2, and MSH6. The...

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Veröffentlicht in:	Journal of clinical oncology 2001-10, Vol.19 (20), p.4074-4080
Hauptverfasser:	VASEN, H. F. A, STORMORKEN, A, MENKO, F. H, NAGENGAST, F. M, KLEIBEUKER, J. H, GRIFFIOEN, G, TAAL, B. G, MOLLER, P, WIJNEN, J. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adolescent Adult Age Factors Aged Aged, 80 and over Base Pair Mismatch - genetics Biological and medical sciences Carrier Proteins Child Child, Preschool Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Repair - genetics DNA-Binding Proteins Epidemiology Female Heterozygote Humans Male Medical sciences Middle Aged Mutation MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - genetics Netherlands - epidemiology Nuclear Proteins Proto-Oncogene Proteins - genetics Registries Risk Factors Sex Factors Tumors
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