Characteristics of Surfactant Protein A and D Binding to Lipoteichoic Acid and Peptidoglycan, 2 Major Cell Wall Components of Gram-Positive Bacteria

Infection with gram-positive bacteria is a major cause of pneumonia. Surfactant proteins A (SP-A) and D (SP-D) are thought to play an important role in the innate immunity of the lung. Both proteins can bind to gram-positive bacteria. Until now, it was not known with which surface component(s) of gr...

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Veröffentlicht in:	The Journal of infectious diseases 2001-11, Vol.184 (9), p.1143-1151
Hauptverfasser:	de Wetering, J. Koenraad van, van Eijk, Martin, van Golde, Lambert M. G., Hartung, Thomas, van Strijp, Jos A. G., Batenburg, Joseph J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacillus subtilis Bacillus subtilis - metabolism Bacteria Bacteriology Binding, Competitive Biological and medical sciences Calcium Calcium - metabolism Carbohydrate Metabolism Cell Wall - chemistry Cell wall components Cell walls Divalent cations Fundamental and applied biological sciences. Psychology Glycoproteins - metabolism Gram positive bacteria Humans Infections Lipopolysaccharides - metabolism lipoteichoic acid Lungs Major Articles Medical sciences Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peptidoglycan - metabolism peptidoglycans Pharmacology. Drug treatments protein A protein D Proteolipids - metabolism Pulmonary Surfactant-Associated Protein A Pulmonary Surfactant-Associated Protein D Pulmonary Surfactant-Associated Proteins Pulmonary surfactants Pulmonary Surfactants - metabolism Staphylococcus aureus Staphylococcus aureus - metabolism Surfactants Teichoic Acids - metabolism
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