Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect

The immunosuppressant rapamycin, an immunophilin-binding antibiotic, has been studied in follicular B-cell lymphoma lines that express the highest level of the BCL-2 protein. The growth rate of human follicular B-cell lymphoma lines was slowed more efficiently than that of other human B-cell lines o...

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Veröffentlicht in:	European journal of cancer (1990) 2001-11, Vol.37 (16), p.2121-2128
Hauptverfasser:	Calastretti, A, Rancati, F, Ceriani, M.C, Asnaghi, L, Canti, G, Nicolin, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Apoptosis Apoptosis - drug effects B-cell lymphoma BCL-2 protein Biological and medical sciences Caspases - metabolism Cell Cycle - drug effects Cell Division - drug effects G1 arrest G1 Phase - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Immunosuppressive Agents - pharmacology Immunotherapy Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Medical sciences Neoplasm Proteins - drug effects Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rapamycin RNA, Messenger - genetics RNA, Neoplasm - genetics Sirolimus - pharmacology Tumor Cells, Cultured
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