Microstructural investigations of strain-related collagen mineralization
Distraction osteogenesis in rabbit mandibles after osteotomy can be used as an experimental model to study the microstructural features of mineralization of callus under defined mechanical loads. Our aim was to study the relation between the micromotions in the gap and the resulting features of mine...
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| Veröffentlicht in: | British journal of oral & maxillofacial surgery 2001-10, Vol.39 (5), p.381-389 |
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| creator | Meyer, U. Wiesmann, H.P. Meyer, T. Schulze-Osthoff, D. Jäsche, J. Kruse-Lösler, B. Joos, U. |
| description | Distraction osteogenesis in rabbit mandibles after osteotomy can be used as an experimental model to study the microstructural features of mineralization of callus under defined mechanical loads. Our aim was to study the relation between the micromotions in the gap and the resulting features of mineralization of the matrix. We found that assembly of collagen and formation of crystals depended on the magnitude of the mechanical stress applied. At physiological bone strains (2000 μstrains), the callus had collagen type I in a mature bone-like extracellular arrangement, whereas at 20000 μstrains bundles were orientated predominantly towards the tension vector. Maximum loads (200000 μstrains) resulted in disorganized assembly of the collagen. Quantitative energy-dispersive analysis by X-rays confirmed that high strains were associated with substantially lower concentrations of calcium and phosphate. In contrast to bone-like apatitic formation of crystals at physiological strains, significantly fewer but larger crystals were detected by electron diffraction analysis in samples exposed to high strains. We suggest that mechanical stress regulates the assembly and mineralization of collagen during distraction osteogenesis. |
| doi_str_mv | 10.1054/bjom.2001.0627 |
| format | Article |
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Our aim was to study the relation between the micromotions in the gap and the resulting features of mineralization of the matrix. We found that assembly of collagen and formation of crystals depended on the magnitude of the mechanical stress applied. At physiological bone strains (2000 μstrains), the callus had collagen type I in a mature bone-like extracellular arrangement, whereas at 20000 μstrains bundles were orientated predominantly towards the tension vector. Maximum loads (200000 μstrains) resulted in disorganized assembly of the collagen. Quantitative energy-dispersive analysis by X-rays confirmed that high strains were associated with substantially lower concentrations of calcium and phosphate. In contrast to bone-like apatitic formation of crystals at physiological strains, significantly fewer but larger crystals were detected by electron diffraction analysis in samples exposed to high strains. We suggest that mechanical stress regulates the assembly and mineralization of collagen during distraction osteogenesis.</description><identifier>ISSN: 0266-4356</identifier><identifier>EISSN: 1532-1940</identifier><identifier>DOI: 10.1054/bjom.2001.0627</identifier><identifier>PMID: 11601821</identifier><identifier>CODEN: BJOSEY</identifier><language>eng</language><publisher>Londonc: Elsevier Ltd</publisher><subject>Animals ; Apatites - chemistry ; Biological and medical sciences ; Bone Matrix - chemistry ; Bone Matrix - ultrastructure ; Bony Callus - chemistry ; Bony Callus - ultrastructure ; Calcification, Physiologic - physiology ; Calcium - analysis ; Collagen - chemistry ; Collagen - ultrastructure ; Collagen Type I - chemistry ; Collagen Type I - ultrastructure ; Crystallization ; Crystallography ; Dentistry ; Durapatite - chemistry ; Electron Probe Microanalysis ; Ent. Stomatology ; Female ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Investigative techniques, diagnostic techniques (general aspects) ; Mandible - chemistry ; Mandible - surgery ; Mandible - ultrastructure ; Maxillofacial surgery. Dental surgery. Orthodontics ; Medical sciences ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Models, Animal ; Movement ; Osteogenesis, Distraction ; Osteotomy ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phosphates - analysis ; Rabbits ; Stress, Mechanical ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; X-Ray Diffraction</subject><ispartof>British journal of oral & maxillofacial surgery, 2001-10, Vol.39 (5), p.381-389</ispartof><rights>2001 The British Association of Oral and Maxillofacial Surgeons</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 The British Association of Oral and Maxillofacial Surgeons.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-e852513f8f6a4c9a47b442a7e9cca90e042d1d1184b0a569d783d88dfabe55c03</citedby><cites>FETCH-LOGICAL-c436t-e852513f8f6a4c9a47b442a7e9cca90e042d1d1184b0a569d783d88dfabe55c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1054/bjom.2001.0627$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14132123$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11601821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyer, U.</creatorcontrib><creatorcontrib>Wiesmann, H.P.</creatorcontrib><creatorcontrib>Meyer, T.</creatorcontrib><creatorcontrib>Schulze-Osthoff, D.</creatorcontrib><creatorcontrib>Jäsche, J.</creatorcontrib><creatorcontrib>Kruse-Lösler, B.</creatorcontrib><creatorcontrib>Joos, U.</creatorcontrib><title>Microstructural investigations of strain-related collagen mineralization</title><title>British journal of oral & maxillofacial surgery</title><addtitle>Br J Oral Maxillofac Surg</addtitle><description>Distraction osteogenesis in rabbit mandibles after osteotomy can be used as an experimental model to study the microstructural features of mineralization of callus under defined mechanical loads. Our aim was to study the relation between the micromotions in the gap and the resulting features of mineralization of the matrix. We found that assembly of collagen and formation of crystals depended on the magnitude of the mechanical stress applied. At physiological bone strains (2000 μstrains), the callus had collagen type I in a mature bone-like extracellular arrangement, whereas at 20000 μstrains bundles were orientated predominantly towards the tension vector. Maximum loads (200000 μstrains) resulted in disorganized assembly of the collagen. Quantitative energy-dispersive analysis by X-rays confirmed that high strains were associated with substantially lower concentrations of calcium and phosphate. In contrast to bone-like apatitic formation of crystals at physiological strains, significantly fewer but larger crystals were detected by electron diffraction analysis in samples exposed to high strains. We suggest that mechanical stress regulates the assembly and mineralization of collagen during distraction osteogenesis.</description><subject>Animals</subject><subject>Apatites - chemistry</subject><subject>Biological and medical sciences</subject><subject>Bone Matrix - chemistry</subject><subject>Bone Matrix - ultrastructure</subject><subject>Bony Callus - chemistry</subject><subject>Bony Callus - ultrastructure</subject><subject>Calcification, Physiologic - physiology</subject><subject>Calcium - analysis</subject><subject>Collagen - chemistry</subject><subject>Collagen - ultrastructure</subject><subject>Collagen Type I - chemistry</subject><subject>Collagen Type I - ultrastructure</subject><subject>Crystallization</subject><subject>Crystallography</subject><subject>Dentistry</subject><subject>Durapatite - chemistry</subject><subject>Electron Probe Microanalysis</subject><subject>Ent. Stomatology</subject><subject>Female</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mandible - chemistry</subject><subject>Mandible - surgery</subject><subject>Mandible - ultrastructure</subject><subject>Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>Models, Animal</subject><subject>Movement</subject><subject>Osteogenesis, Distraction</subject><subject>Osteotomy</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Phosphates - analysis</subject><subject>Rabbits</subject><subject>Stress, Mechanical</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>X-Ray Diffraction</subject><issn>0266-4356</issn><issn>1532-1940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhq2qqGyh1x5RLu0ty4w_EudYIcpWouoFzpZjT1Ze5QPsBKn99TjsSpx6msM87-idh7GvCFsEJa_bwzRsOQBuoeL1B7ZBJXiJjYSPbAO8qkopVHXOPqd0AADFUX1i54gVoOa4YbvfwcUpzXFx8xJtX4TxhdIc9nYO05iKqSvy0oaxjNTbmXzhpr63exqLIYyUE-HfG3rJzjrbJ_pymhfs8eftw82uvP9z9-vmx33ppKjmkrTiCkWnu8pK11hZt1JyW1PjnG2AQHKPHlHLFqyqGl9r4bX2nW1JKQfign0_3n2K0_OSq5ohJEe500jTkkzNsdECdAa3R3D9L0XqzFMMg41_DYJZ3ZnVnVndmdVdDlydLi_tQP4dP8nKwLcTYJOzfRft6EJ65yQKjlxkTh85yh5eAkWTXKDRkQ-R3Gz8FP7X4RXQP4vL</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Meyer, U.</creator><creator>Wiesmann, H.P.</creator><creator>Meyer, T.</creator><creator>Schulze-Osthoff, D.</creator><creator>Jäsche, J.</creator><creator>Kruse-Lösler, B.</creator><creator>Joos, U.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Microstructural investigations of strain-related collagen mineralization</title><author>Meyer, U. ; Wiesmann, H.P. ; Meyer, T. ; Schulze-Osthoff, D. ; Jäsche, J. ; Kruse-Lösler, B. ; Joos, U.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-e852513f8f6a4c9a47b442a7e9cca90e042d1d1184b0a569d783d88dfabe55c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Apatites - chemistry</topic><topic>Biological and medical sciences</topic><topic>Bone Matrix - chemistry</topic><topic>Bone Matrix - ultrastructure</topic><topic>Bony Callus - chemistry</topic><topic>Bony Callus - ultrastructure</topic><topic>Calcification, Physiologic - physiology</topic><topic>Calcium - analysis</topic><topic>Collagen - chemistry</topic><topic>Collagen - ultrastructure</topic><topic>Collagen Type I - chemistry</topic><topic>Collagen Type I - ultrastructure</topic><topic>Crystallization</topic><topic>Crystallography</topic><topic>Dentistry</topic><topic>Durapatite - chemistry</topic><topic>Electron Probe Microanalysis</topic><topic>Ent. Stomatology</topic><topic>Female</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mandible - chemistry</topic><topic>Mandible - surgery</topic><topic>Mandible - ultrastructure</topic><topic>Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>Models, Animal</topic><topic>Movement</topic><topic>Osteogenesis, Distraction</topic><topic>Osteotomy</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Phosphates - analysis</topic><topic>Rabbits</topic><topic>Stress, Mechanical</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyer, U.</creatorcontrib><creatorcontrib>Wiesmann, H.P.</creatorcontrib><creatorcontrib>Meyer, T.</creatorcontrib><creatorcontrib>Schulze-Osthoff, D.</creatorcontrib><creatorcontrib>Jäsche, J.</creatorcontrib><creatorcontrib>Kruse-Lösler, B.</creatorcontrib><creatorcontrib>Joos, U.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of oral & maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyer, U.</au><au>Wiesmann, H.P.</au><au>Meyer, T.</au><au>Schulze-Osthoff, D.</au><au>Jäsche, J.</au><au>Kruse-Lösler, B.</au><au>Joos, U.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstructural investigations of strain-related collagen mineralization</atitle><jtitle>British journal of oral & maxillofacial surgery</jtitle><addtitle>Br J Oral Maxillofac Surg</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>39</volume><issue>5</issue><spage>381</spage><epage>389</epage><pages>381-389</pages><issn>0266-4356</issn><eissn>1532-1940</eissn><coden>BJOSEY</coden><abstract>Distraction osteogenesis in rabbit mandibles after osteotomy can be used as an experimental model to study the microstructural features of mineralization of callus under defined mechanical loads. Our aim was to study the relation between the micromotions in the gap and the resulting features of mineralization of the matrix. We found that assembly of collagen and formation of crystals depended on the magnitude of the mechanical stress applied. At physiological bone strains (2000 μstrains), the callus had collagen type I in a mature bone-like extracellular arrangement, whereas at 20000 μstrains bundles were orientated predominantly towards the tension vector. Maximum loads (200000 μstrains) resulted in disorganized assembly of the collagen. Quantitative energy-dispersive analysis by X-rays confirmed that high strains were associated with substantially lower concentrations of calcium and phosphate. In contrast to bone-like apatitic formation of crystals at physiological strains, significantly fewer but larger crystals were detected by electron diffraction analysis in samples exposed to high strains. We suggest that mechanical stress regulates the assembly and mineralization of collagen during distraction osteogenesis.</abstract><cop>Londonc</cop><pub>Elsevier Ltd</pub><pmid>11601821</pmid><doi>10.1054/bjom.2001.0627</doi><tpages>9</tpages></addata></record> |
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| ispartof | British journal of oral & maxillofacial surgery, 2001-10, Vol.39 (5), p.381-389 |
| issn | 0266-4356 1532-1940 |
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| subjects | Animals Apatites - chemistry Biological and medical sciences Bone Matrix - chemistry Bone Matrix - ultrastructure Bony Callus - chemistry Bony Callus - ultrastructure Calcification, Physiologic - physiology Calcium - analysis Collagen - chemistry Collagen - ultrastructure Collagen Type I - chemistry Collagen Type I - ultrastructure Crystallization Crystallography Dentistry Durapatite - chemistry Electron Probe Microanalysis Ent. Stomatology Female Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Investigative techniques, diagnostic techniques (general aspects) Mandible - chemistry Mandible - surgery Mandible - ultrastructure Maxillofacial surgery. Dental surgery. Orthodontics Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Models, Animal Movement Osteogenesis, Distraction Osteotomy Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphates - analysis Rabbits Stress, Mechanical Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases X-Ray Diffraction |
| title | Microstructural investigations of strain-related collagen mineralization |
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