A Single Amino Acid Substitution in the Viral Polymerase Creates a Temperature-Sensitive and Attenuated Recombinant Bovine Parainfluenza Virus Type 3

Bovine parainfluenza virus type 3 (bPIV3) is under development as a live virus vaccine vector. The RNA genome of a recombinant bPIV3 harbored four nucleotide changes, one of which resulted in a mutation of the viral polymerase (A. A. Haller et al., 2000, J. Virol. 74, 11626–11635). The contribution...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2001-09, Vol.288 (2), p.342-350
Hauptverfasser:	Haller, Aurelia A., MacPhail, Mia, Mitiku, Misrach, Tang, Roderick S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals attenuation Base Sequence bovine parainfluenza type 3 Bovine parainfluenza virus 3 Cattle Cercopithecus aethiops Cricetinae HeLa Cells Humans live virus vaccine vector Mesocricetus Molecular Sequence Data Parainfluenza Virus 3, Bovine - enzymology Parainfluenza Virus 3, Bovine - genetics Parainfluenza Virus 3, Bovine - physiology Parainfluenza Virus 3, Human - genetics Parainfluenza Virus 3, Human - physiology polymerase mutation Recombination, Genetic RNA Replicase - genetics RNA Replicase - metabolism RNA-Directed DNA Polymerase - genetics RNA-Directed DNA Polymerase - metabolism Temperature temperature sensitivity Vero Cells Virus Replication
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!