Successful treatment of solar urticaria by extracorporeal photochemotherapy (photopheresis) - a case report

: Solar urticaria is characterized by erythema and whealing immediately after exposure to ultraviolet radiation and/or visible light. We report about a patient with severe solar urticaria, who was highly sensitive to both UVA radiation and visible light with a Minimal Urticaria Dose (MUD) of 7 J/cm2...

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Veröffentlicht in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2002-08, Vol.18 (4), p.196-198
Hauptverfasser: Mang, R., Stege, H., Budde, M.-A., Ruzicka, T., Krutmann, J.
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container_end_page 198
container_issue 4
container_start_page 196
container_title Photodermatology, photoimmunology & photomedicine
container_volume 18
creator Mang, R.
Stege, H.
Budde, M.-A.
Ruzicka, T.
Krutmann, J.
description : Solar urticaria is characterized by erythema and whealing immediately after exposure to ultraviolet radiation and/or visible light. We report about a patient with severe solar urticaria, who was highly sensitive to both UVA radiation and visible light with a Minimal Urticaria Dose (MUD) of 7 J/cm2 UVA. Management of this patient was extremely difficult because standard treatment with oral antihistamines, hardening with UVA, UVB, visible light or oral PUVA and even oral cyclosporin A were completely ineffective. We therefore decided to perform extracorporeal photochemotherapy (photopheresis, ECP). After nine treatment cycles with photopheresis the MUD increased from 7 J/cm2 UVA before treatment to 22 J/cm2 UVA. This hardening effect was associated with a significant decrease of the frequency and severity of whealing and the accompanying symptoms (pain, fatigue, pruritus). Conclusion: Photopheresis might be of some benefit in selected patients with otherwise intractable solar urticaria.
doi_str_mv 10.1034/j.1600-0781.2002.00683.x
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We report about a patient with severe solar urticaria, who was highly sensitive to both UVA radiation and visible light with a Minimal Urticaria Dose (MUD) of 7 J/cm2 UVA. Management of this patient was extremely difficult because standard treatment with oral antihistamines, hardening with UVA, UVB, visible light or oral PUVA and even oral cyclosporin A were completely ineffective. We therefore decided to perform extracorporeal photochemotherapy (photopheresis, ECP). After nine treatment cycles with photopheresis the MUD increased from 7 J/cm2 UVA before treatment to 22 J/cm2 UVA. This hardening effect was associated with a significant decrease of the frequency and severity of whealing and the accompanying symptoms (pain, fatigue, pruritus). 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We report about a patient with severe solar urticaria, who was highly sensitive to both UVA radiation and visible light with a Minimal Urticaria Dose (MUD) of 7 J/cm2 UVA. Management of this patient was extremely difficult because standard treatment with oral antihistamines, hardening with UVA, UVB, visible light or oral PUVA and even oral cyclosporin A were completely ineffective. We therefore decided to perform extracorporeal photochemotherapy (photopheresis, ECP). After nine treatment cycles with photopheresis the MUD increased from 7 J/cm2 UVA before treatment to 22 J/cm2 UVA. This hardening effect was associated with a significant decrease of the frequency and severity of whealing and the accompanying symptoms (pain, fatigue, pruritus). Conclusion: Photopheresis might be of some benefit in selected patients with otherwise intractable solar urticaria.</description><subject>Biological and medical sciences</subject><subject>Diseases of the skin. Cosmetics</subject><subject>extracorporeal photopheresis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Photopheresis</subject><subject>Photosensitivity Disorders - drug therapy</subject><subject>Photosensitivity Disorders - pathology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Diet therapy and various other treatments (general aspects)</topic><topic>Skin - pathology</topic><topic>solar urticaria</topic><topic>Urticaria - drug therapy</topic><topic>Urticaria - etiology</topic><topic>Urticaria - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mang, R.</creatorcontrib><creatorcontrib>Stege, H.</creatorcontrib><creatorcontrib>Budde, M.-A.</creatorcontrib><creatorcontrib>Ruzicka, T.</creatorcontrib><creatorcontrib>Krutmann, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mang, R.</au><au>Stege, H.</au><au>Budde, M.-A.</au><au>Ruzicka, T.</au><au>Krutmann, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of solar urticaria by extracorporeal photochemotherapy (photopheresis) - a case report</atitle><jtitle>Photodermatology, photoimmunology &amp; photomedicine</jtitle><addtitle>Photodermatol Photoimmunol Photomed</addtitle><date>2002-08</date><risdate>2002</risdate><volume>18</volume><issue>4</issue><spage>196</spage><epage>198</epage><pages>196-198</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>: Solar urticaria is characterized by erythema and whealing immediately after exposure to ultraviolet radiation and/or visible light. We report about a patient with severe solar urticaria, who was highly sensitive to both UVA radiation and visible light with a Minimal Urticaria Dose (MUD) of 7 J/cm2 UVA. Management of this patient was extremely difficult because standard treatment with oral antihistamines, hardening with UVA, UVB, visible light or oral PUVA and even oral cyclosporin A were completely ineffective. We therefore decided to perform extracorporeal photochemotherapy (photopheresis, ECP). After nine treatment cycles with photopheresis the MUD increased from 7 J/cm2 UVA before treatment to 22 J/cm2 UVA. This hardening effect was associated with a significant decrease of the frequency and severity of whealing and the accompanying symptoms (pain, fatigue, pruritus). 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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Biological and medical sciences
Diseases of the skin. Cosmetics
extracorporeal photopheresis
Humans
Male
Medical sciences
Middle Aged
Photopheresis
Photosensitivity Disorders - drug therapy
Photosensitivity Disorders - pathology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Skin - pathology
solar urticaria
Urticaria - drug therapy
Urticaria - etiology
Urticaria - pathology
title Successful treatment of solar urticaria by extracorporeal photochemotherapy (photopheresis) - a case report
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