Interferon-γ production is suppressed in thermally injured mice: Decreased production of regulatory cytokines and corresponding receptors

Thermal injury to 40% or more of the total body surface area poses a significant risk for the development of opportunistic infections that increase complications and mortality. Altered cytokine induction profiles, including suppression of the Th1 cytokines IFN-gamma and IL-12 and elevations in the a...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2002-10, Vol.18 (4), p.322-330
Hauptverfasser:	TOLIVER-KINSKY, Tracy E, VARMA, Tushar K, LIN, Cheng Y, HERNDON, David N, SHERWOOD, Edward R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Burns Burns - metabolism Cells, Cultured Coculture Techniques Cytokines - biosynthesis Cytokines - genetics Female Interferon-gamma - biosynthesis Interleukin-10 - metabolism Interleukin-12 - metabolism Killer Cells, Natural - metabolism Lymphocytes - metabolism Macrophages - metabolism Medical sciences Mice Mice, Inbred BALB C Pseudomonas aeruginosa - pathogenicity Receptors, Cytokine - metabolism Spleen - cytology Spleen - metabolism Traumas. Diseases due to physical agents
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