Facile Approach to Enantiomerically Pure α-Amino Ketones by Friedel−Crafts Aminoacylation and Their Conversion into Peptidyl Ketones

In this article we describe a versatile and straightforward preparative approach to chiral aryl α-amino ketones via a Friedel−Crafts-type reaction of stable and enantiomerically pure N-Fmoc protected l-amino acid chlorides with toluene in the presence of aluminum trichloride. The developed methodolo...

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Veröffentlicht in:	Journal of organic chemistry 2001-10, Vol.66 (21), p.7002-7007
Hauptverfasser:	Di Gioia, Maria Luisa, Leggio, Antonella, Liguori, Angelo, Napoli, Anna, Siciliano, Carlo, Sindona, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Dipeptides - chemical synthesis Ketones - chemical synthesis Ketones - chemistry Peptides - chemical synthesis Peptides - chemistry Stereoisomerism
Online-Zugang:	Volltext
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