Magnetic resonance spectroscopy: an in vivo tool for monitoring cerebral injury in SIV-infected macaques
: The purpose of our study was to demonstrate the feasibility of using in vivo proton Magnetic Resonance Spectroscopy (MRS) to monitor the brain manifestations of SIV infection in the macaque model of AIDS. Previous spectroscopy work on macaque brain tissue and in vivo work in humans is reviewed to...
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| Veröffentlicht in: | Journal of medical primatology 2002-08, Vol.31 (4-5), p.228-236 |
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| container_issue | 4-5 |
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| container_title | Journal of medical primatology |
| container_volume | 31 |
| creator | Greco, J.B. Sakaie, K.E. Aminipour, S. Lee, P.L. Chang, L.L. He, J. Westmoreland, S. Lackner, A.A. Gonzalez, R.G. |
| description | : The purpose of our study was to demonstrate the feasibility of using in vivo proton Magnetic Resonance Spectroscopy (MRS) to monitor the brain manifestations of SIV infection in the macaque model of AIDS. Previous spectroscopy work on macaque brain tissue and in vivo work in humans is reviewed to provide the motivation and context for this study. We collected 34 MRS data sets on 14 uninfected rhesus macaques. From this data, we demonstrate that we are capable of detecting changes similar to those observed in human MRS studies for most metabolites using less than 10 animals. The juvenile macaques utilized in this study demonstrate age‐related changes in the levels of N‐acetyl aspartate (NAA), a neuronal marker. The quantity and distribution of neurochemicals in the macaque are found to be slightly, but significantly, different than in the human. |
| doi_str_mv | 10.1034/j.1600-0684.2002.02009.x |
| format | Article |
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Previous spectroscopy work on macaque brain tissue and in vivo work in humans is reviewed to provide the motivation and context for this study. We collected 34 MRS data sets on 14 uninfected rhesus macaques. From this data, we demonstrate that we are capable of detecting changes similar to those observed in human MRS studies for most metabolites using less than 10 animals. The juvenile macaques utilized in this study demonstrate age‐related changes in the levels of N‐acetyl aspartate (NAA), a neuronal marker. The quantity and distribution of neurochemicals in the macaque are found to be slightly, but significantly, different than in the human.</description><subject>Aging</subject><subject>Animals</subject><subject>Brain Diseases - complications</subject><subject>Brain Diseases - pathology</subject><subject>Brain Diseases - virology</subject><subject>choline</subject><subject>Humans</subject><subject>juvenile</subject><subject>Macaca mulatta - virology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>N-acetyl-aspartate</subject><subject>Simian Acquired Immunodeficiency Syndrome - complications</subject><subject>Simian Acquired Immunodeficiency Syndrome - pathology</subject><subject>Simian Immunodeficiency Virus - physiology</subject><issn>0047-2565</issn><issn>1600-0684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAURS0EokPhF5BX7JI-O3Ecs0BCFbSFtiC1lIqN5TgvxUMST-1Mmfl7HGZUtmxsS773PL1DCGWQMyjKo2XOKoAMqrrMOQDPIZ0q3zwhi8ePp2QBUMqMi0ockBcxLgFSV5XPyQHjhQJRigX5eWHuRpycpQGjH81okcYV2in4aP1q-5aakbqRPrgHTyfve9r5QAc_uskHN95RiwGbYPoUWq7Dds5end1kbuwSBFs6GGvu1xhfkmed6SO-2t-H5NvHD9fHp9n5l5Oz4_fnmS2hVFkrGt5iVdRcqlZIxNow2xmJUIFQ2HJQXVeyVvJaNgoZMtsUAmRRSoXWmuKQvNlxV8HPcyc9uGix782Ifh215ExVTMgUrHdBm1aNATu9Cm4wYasZ6NmyXupZpp5l6tmy_mtZb1L19X7Guhmw_Vfca02Bd7vAb9fj9r_B-tPFV36bngmQ7QAuTrh5BJjwS1eykEJ_vzzRhbi8lT9Ob_Tn4g-dMZwl</recordid><startdate>200208</startdate><enddate>200208</enddate><creator>Greco, J.B.</creator><creator>Sakaie, K.E.</creator><creator>Aminipour, S.</creator><creator>Lee, P.L.</creator><creator>Chang, L.L.</creator><creator>He, J.</creator><creator>Westmoreland, S.</creator><creator>Lackner, A.A.</creator><creator>Gonzalez, R.G.</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200208</creationdate><title>Magnetic resonance spectroscopy: an in vivo tool for monitoring cerebral injury in SIV-infected macaques</title><author>Greco, J.B. ; Sakaie, K.E. ; Aminipour, S. ; Lee, P.L. ; Chang, L.L. ; He, J. ; Westmoreland, S. ; Lackner, A.A. ; Gonzalez, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4049-d5b2de638279d57ee8a1cfa7e06059ed209ff41d7287b9e1e1cb35073479ecca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Brain Diseases - complications</topic><topic>Brain Diseases - pathology</topic><topic>Brain Diseases - virology</topic><topic>choline</topic><topic>Humans</topic><topic>juvenile</topic><topic>Macaca mulatta - virology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>N-acetyl-aspartate</topic><topic>Simian Acquired Immunodeficiency Syndrome - complications</topic><topic>Simian Acquired Immunodeficiency Syndrome - pathology</topic><topic>Simian Immunodeficiency Virus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greco, J.B.</creatorcontrib><creatorcontrib>Sakaie, K.E.</creatorcontrib><creatorcontrib>Aminipour, S.</creatorcontrib><creatorcontrib>Lee, P.L.</creatorcontrib><creatorcontrib>Chang, L.L.</creatorcontrib><creatorcontrib>He, J.</creatorcontrib><creatorcontrib>Westmoreland, S.</creatorcontrib><creatorcontrib>Lackner, A.A.</creatorcontrib><creatorcontrib>Gonzalez, R.G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greco, J.B.</au><au>Sakaie, K.E.</au><au>Aminipour, S.</au><au>Lee, P.L.</au><au>Chang, L.L.</au><au>He, J.</au><au>Westmoreland, S.</au><au>Lackner, A.A.</au><au>Gonzalez, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance spectroscopy: an in vivo tool for monitoring cerebral injury in SIV-infected macaques</atitle><jtitle>Journal of medical primatology</jtitle><addtitle>J Med Primatol</addtitle><date>2002-08</date><risdate>2002</risdate><volume>31</volume><issue>4-5</issue><spage>228</spage><epage>236</epage><pages>228-236</pages><issn>0047-2565</issn><eissn>1600-0684</eissn><abstract>: The purpose of our study was to demonstrate the feasibility of using in vivo proton Magnetic Resonance Spectroscopy (MRS) to monitor the brain manifestations of SIV infection in the macaque model of AIDS. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aging Animals Brain Diseases - complications Brain Diseases - pathology Brain Diseases - virology choline Humans juvenile Macaca mulatta - virology Magnetic Resonance Imaging - methods N-acetyl-aspartate Simian Acquired Immunodeficiency Syndrome - complications Simian Acquired Immunodeficiency Syndrome - pathology Simian Immunodeficiency Virus - physiology |
| title | Magnetic resonance spectroscopy: an in vivo tool for monitoring cerebral injury in SIV-infected macaques |
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