Lack of an association between T-wave alternans and ST-segment depression during exercise-induced ambulatory ischemia
It is known that T-wave alternans (TWA), which identify patients at risk for arrhythmic events, often occur during acute coronary occlusion in association with ST-segment elevation. To test the hypothesis that TWA is associated with a certain state/severity of myocardial infarction/ischemia, we asse...
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| Veröffentlicht in: | Journal of electrocardiology 2000-07, Vol.33 (3), p.261-267 |
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| container_title | Journal of electrocardiology |
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| creator | Ikeda, Takanori Kumagai, Kenta Takami, Mitsuaki Tezuka, Naoki Nakae, Takeshi Sakata, Takao Noro, Mahito Enjoji, Yoshihisa Sugi, Kaoru Yamaguchi, Tetsu |
| description | It is known that T-wave alternans (TWA), which identify patients at risk for arrhythmic events, often occur during acute coronary occlusion in association with ST-segment elevation. To test the hypothesis that TWA is associated with a certain state/severity of myocardial infarction/ischemia, we assessed the association between TWA and ST-segment depression during exercise-induced ambulatory ischemia. Of 351 consecutive patients with coronary artery disease who underwent assessment of microvolt TWA by exercise, 23 patients with effort angina without a history of infarction with ST depression (≥0.1 mV) during TWA test were selected. These patients were compared with 222 postinfarction patients consisting of 38 patients with, and 184 patients, without the ST depression, and 18 normal individuals. The incidence (9%) of determinate TWA in the patients with angina was significantly (P |
| doi_str_mv | 10.1054/jelc.2000.7662 |
| format | Article |
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To test the hypothesis that TWA is associated with a certain state/severity of myocardial infarction/ischemia, we assessed the association between TWA and ST-segment depression during exercise-induced ambulatory ischemia. Of 351 consecutive patients with coronary artery disease who underwent assessment of microvolt TWA by exercise, 23 patients with effort angina without a history of infarction with ST depression (≥0.1 mV) during TWA test were selected. These patients were compared with 222 postinfarction patients consisting of 38 patients with, and 184 patients, without the ST depression, and 18 normal individuals. The incidence (9%) of determinate TWA in the patients with angina was significantly (P<.0001) lower than that (52%) in the postinfarction patients. There was no significant difference between the angina patients and the controls (6%). There was also no difference between the patients with (58%) and without the ST depression (51%) in the postinfarction patients. Moreover, no correlation existed between the TWA voltage and the ST-depression magnitude in both angina and postinfarction patients. We concluded that there is no association between TWA and ambulatory ischemia with ST depression.</description><identifier>ISSN: 0022-0736</identifier><identifier>EISSN: 1532-8430</identifier><identifier>DOI: 10.1054/jelc.2000.7662</identifier><identifier>PMID: 10954379</identifier><identifier>CODEN: JECAB4</identifier><language>eng</language><publisher>Orlando, FL: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Coronary Disease - physiopathology ; Coronary heart disease ; Electrocardiography ; Electrophysiology ; exercise ; Exercise - physiology ; Female ; Heart ; Humans ; ischemia ; Male ; Medical sciences ; Middle Aged ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - physiopathology ; ST segment ; T-wave alternans</subject><ispartof>Journal of electrocardiology, 2000-07, Vol.33 (3), p.261-267</ispartof><rights>2000 Churchill Livingstone</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Churchill Livingstone Inc., Medical Publishers Jul 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-e4486e9e6a5ba04d08fa73d8043be9d04214767b8808fabbf2164df8a0d2bd23</citedby><cites>FETCH-LOGICAL-c396t-e4486e9e6a5ba04d08fa73d8043be9d04214767b8808fabbf2164df8a0d2bd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022073600700203$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1444019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10954379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Takanori</creatorcontrib><creatorcontrib>Kumagai, Kenta</creatorcontrib><creatorcontrib>Takami, Mitsuaki</creatorcontrib><creatorcontrib>Tezuka, Naoki</creatorcontrib><creatorcontrib>Nakae, Takeshi</creatorcontrib><creatorcontrib>Sakata, Takao</creatorcontrib><creatorcontrib>Noro, Mahito</creatorcontrib><creatorcontrib>Enjoji, Yoshihisa</creatorcontrib><creatorcontrib>Sugi, Kaoru</creatorcontrib><creatorcontrib>Yamaguchi, Tetsu</creatorcontrib><title>Lack of an association between T-wave alternans and ST-segment depression during exercise-induced ambulatory ischemia</title><title>Journal of electrocardiology</title><addtitle>J Electrocardiol</addtitle><description>It is known that T-wave alternans (TWA), which identify patients at risk for arrhythmic events, often occur during acute coronary occlusion in association with ST-segment elevation. To test the hypothesis that TWA is associated with a certain state/severity of myocardial infarction/ischemia, we assessed the association between TWA and ST-segment depression during exercise-induced ambulatory ischemia. Of 351 consecutive patients with coronary artery disease who underwent assessment of microvolt TWA by exercise, 23 patients with effort angina without a history of infarction with ST depression (≥0.1 mV) during TWA test were selected. These patients were compared with 222 postinfarction patients consisting of 38 patients with, and 184 patients, without the ST depression, and 18 normal individuals. The incidence (9%) of determinate TWA in the patients with angina was significantly (P<.0001) lower than that (52%) in the postinfarction patients. There was no significant difference between the angina patients and the controls (6%). There was also no difference between the patients with (58%) and without the ST depression (51%) in the postinfarction patients. Moreover, no correlation existed between the TWA voltage and the ST-depression magnitude in both angina and postinfarction patients. We concluded that there is no association between TWA and ambulatory ischemia with ST depression.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Electrocardiography</subject><subject>Electrophysiology</subject><subject>exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>ischemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>ST segment</subject><subject>T-wave alternans</subject><issn>0022-0736</issn><issn>1532-8430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp10UuLFDEUBeAgitOObl1KEHFXbV6dqlrK4AsaXNj7cJPcGtNWJW1SNeP8e1N0gyK4yiLfvSTnEPKSsy1nO_XuiKPbCsbYttVaPCIbvpOi6ZRkj8mGMSEa1kp9RZ6VcqyqF614Sq4463dKtv2GLHtwP2gaKEQKpSQXYA4pUovzPWKkh-Ye7pDCOGOOEEt1nn47NAVvJ4wz9XjKWMo64pcc4i3FX5hdKNiE6BeHnsJklxHmlB9oKO47TgGekycDjAVfXM5rcvj44XDzudl__fTl5v2-cbLXc4NKdRp71LCzwJRn3QCt9B1T0mLvmRJctbq1XbfeWDsIrpUfOmBeWC_kNXl7XnvK6eeCZTZTfQGOI0RMSzGt4L3milf4-h94TEv971hMXcl7qYWuaHtGLqdSMg7mlMME-cFwZtYyzFqGWcswaxl14NVl62In9H_xc_oVvLkAKA7GIUOsyf1xSinGV9adGdao7gJmU1zAWLMNGd1sfAr_e8JvEdymdg</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Ikeda, Takanori</creator><creator>Kumagai, Kenta</creator><creator>Takami, Mitsuaki</creator><creator>Tezuka, Naoki</creator><creator>Nakae, Takeshi</creator><creator>Sakata, Takao</creator><creator>Noro, Mahito</creator><creator>Enjoji, Yoshihisa</creator><creator>Sugi, Kaoru</creator><creator>Yamaguchi, Tetsu</creator><general>Elsevier Inc</general><general>Churchill Livingstone</general><general>Elsevier Science Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Lack of an association between T-wave alternans and ST-segment depression during exercise-induced ambulatory ischemia</title><author>Ikeda, Takanori ; Kumagai, Kenta ; Takami, Mitsuaki ; Tezuka, Naoki ; Nakae, Takeshi ; Sakata, Takao ; Noro, Mahito ; Enjoji, Yoshihisa ; Sugi, Kaoru ; Yamaguchi, Tetsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-e4486e9e6a5ba04d08fa73d8043be9d04214767b8808fabbf2164df8a0d2bd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Electrocardiography</topic><topic>Electrophysiology</topic><topic>exercise</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>ischemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>ST segment</topic><topic>T-wave alternans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Takanori</creatorcontrib><creatorcontrib>Kumagai, Kenta</creatorcontrib><creatorcontrib>Takami, Mitsuaki</creatorcontrib><creatorcontrib>Tezuka, Naoki</creatorcontrib><creatorcontrib>Nakae, Takeshi</creatorcontrib><creatorcontrib>Sakata, Takao</creatorcontrib><creatorcontrib>Noro, Mahito</creatorcontrib><creatorcontrib>Enjoji, Yoshihisa</creatorcontrib><creatorcontrib>Sugi, Kaoru</creatorcontrib><creatorcontrib>Yamaguchi, Tetsu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of electrocardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Takanori</au><au>Kumagai, Kenta</au><au>Takami, Mitsuaki</au><au>Tezuka, Naoki</au><au>Nakae, Takeshi</au><au>Sakata, Takao</au><au>Noro, Mahito</au><au>Enjoji, Yoshihisa</au><au>Sugi, Kaoru</au><au>Yamaguchi, Tetsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of an association between T-wave alternans and ST-segment depression during exercise-induced ambulatory ischemia</atitle><jtitle>Journal of electrocardiology</jtitle><addtitle>J Electrocardiol</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>33</volume><issue>3</issue><spage>261</spage><epage>267</epage><pages>261-267</pages><issn>0022-0736</issn><eissn>1532-8430</eissn><coden>JECAB4</coden><abstract>It is known that T-wave alternans (TWA), which identify patients at risk for arrhythmic events, often occur during acute coronary occlusion in association with ST-segment elevation. To test the hypothesis that TWA is associated with a certain state/severity of myocardial infarction/ischemia, we assessed the association between TWA and ST-segment depression during exercise-induced ambulatory ischemia. Of 351 consecutive patients with coronary artery disease who underwent assessment of microvolt TWA by exercise, 23 patients with effort angina without a history of infarction with ST depression (≥0.1 mV) during TWA test were selected. These patients were compared with 222 postinfarction patients consisting of 38 patients with, and 184 patients, without the ST depression, and 18 normal individuals. The incidence (9%) of determinate TWA in the patients with angina was significantly (P<.0001) lower than that (52%) in the postinfarction patients. There was no significant difference between the angina patients and the controls (6%). There was also no difference between the patients with (58%) and without the ST depression (51%) in the postinfarction patients. Moreover, no correlation existed between the TWA voltage and the ST-depression magnitude in both angina and postinfarction patients. We concluded that there is no association between TWA and ambulatory ischemia with ST depression.</abstract><cop>Orlando, FL</cop><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>10954379</pmid><doi>10.1054/jelc.2000.7662</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of electrocardiology, 2000-07, Vol.33 (3), p.261-267 |
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| subjects | Biological and medical sciences Cardiology. Vascular system Coronary Disease - physiopathology Coronary heart disease Electrocardiography Electrophysiology exercise Exercise - physiology Female Heart Humans ischemia Male Medical sciences Middle Aged Myocardial Ischemia - diagnosis Myocardial Ischemia - physiopathology ST segment T-wave alternans |
| title | Lack of an association between T-wave alternans and ST-segment depression during exercise-induced ambulatory ischemia |
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