Estrogen-Dependent Regulation of Neurokinin 3 Receptor-Mediated Uterine Contractility in the Rat

The receptors for neurokinin 1 (NK1-R), neurokinin 2 (NK2-R), and neurokinin 3 (NK3-R) are expressed and functionally active in the uterus, promoting strong contractions of the myometrium. Previously, we demonstrated that myometrial contractility activated by the NK-Rs is regulated by estrogen. In t...

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Veröffentlicht in:	Biology of reproduction 2002-11, Vol.67 (5), p.1480-1487
Hauptverfasser:	CRANE, Linda H, WILLIAMS, Melanie J, NIMMO, Alan J, HAMLIN, Gary P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Biological and medical sciences Capsaicin - pharmacology Dose-Response Relationship, Drug Estrogens - pharmacology Estrogens - physiology Estrus - physiology Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation In Vitro Techniques Mammalian female genital system Ovariectomy Peptide Fragments - pharmacology Rats Rats, Sprague-Dawley Receptors, Neurokinin-1 - drug effects Receptors, Neurokinin-1 - metabolism Receptors, Neurokinin-2 - drug effects Receptors, Neurokinin-2 - metabolism Receptors, Neurokinin-3 - agonists Receptors, Neurokinin-3 - metabolism Substance P - analogs & derivatives Substance P - pharmacology Uterine Contraction - drug effects Uterine Contraction - physiology Uterus - drug effects Uterus - physiology Vertebrates: reproduction
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