Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer

G207 and NV1020 are two replication-competent, multimutant oncolytic herpes simplex viruses evaluated in the current studies for their anticancer effects in the treatment of gastric cancer. Deletion of both gamma(1)34.5 genes and inactivation of ICP6 (ribonucleotide reductase) allows G207 to selecti...

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Veröffentlicht in:	Cancer gene therapy 2002-11, Vol.9 (11), p.935-945
Hauptverfasser:	Bennett, Joseph J, Delman, Keith A, Burt, Bryan M, Mariotti, Adam, Malhotra, Sandeep, Zager, Jonathan, Petrowsky, Henrik, Mastorides, Stephen, Federoff, Howard, Fong, Yuman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity Cell Survival Cytotoxicity Cytotoxicity, Immunologic Disease-Free Survival Escherichia coli - genetics Gastric cancer Gene deletion Genetic engineering Genetic Markers Genetic Therapy - methods Herpes simplex Immunohistochemistry Intravenous administration Malignancy Mice Mice, Nude Oncolysis Peritoneum Replication Simplexvirus - classification Simplexvirus - genetics Stomach Neoplasms - immunology Stomach Neoplasms - pathology Stomach Neoplasms - therapy Time Factors Transplantation, Heterologous Tumor cells Tumor Cells, Cultured Viruses Xenografts
Online-Zugang:	Volltext
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