Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza

Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice. However, despite these defects we found that LTalpha(-/-) mice could survive infection...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-11, Vol.169 (9), p.5236-5243
Hauptverfasser:	Lund, Frances E, Partida-Sánchez, Santiago, Lee, Byung O, Kusser, Kimberly L, Hartson, Louise, Hogan, Robert J, Woodland, David L, Randall, Troy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity - genetics B-Lymphocytes - immunology B-Lymphocytes - virology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - virology Cells, Cultured Cytotoxicity, Immunologic - genetics Epitopes, T-Lymphocyte - immunology Genetic Predisposition to Disease Germinal Center - immunology Germinal Center - metabolism Germinal Center - pathology Immunoglobulin Isotypes - biosynthesis Influenza A virus - immunology Interferon-gamma - biosynthesis Lung - cytology Lung - immunology Lymphotoxin-alpha - deficiency Lymphotoxin-alpha - genetics Lymphotoxin-alpha - physiology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Spleen - abnormalities Spleen - immunology Spleen - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology Time Factors Viral Load
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