The relationship between serum creatinine, serum cystatin C and glomerular filtration rate in pediatric renal transplant recipients: A pilot study
: Serum cystatin C more accurately reflects glomerular filtration rate (GFR) in pediatric renal transplant recipients than serum creatinine. Nineteen pediatric renal transplant recipients, 15 male and 4 female, ranging in age from 8.35 yr to 19.06 yr (median 13.52 yr), were enrolled in the study ove...
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| Veröffentlicht in: | Pediatric transplantation 2002-10, Vol.6 (5), p.392-395 |
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| creator | Krieser, David Rosenberg, Andrew R. Kainer, Gad |
| description | : Serum cystatin C more accurately reflects glomerular filtration rate (GFR) in pediatric renal transplant recipients than serum creatinine. Nineteen pediatric renal transplant recipients, 15 male and 4 female, ranging in age from 8.35 yr to 19.06 yr (median 13.52 yr), were enrolled in the study over an 18‐month period. Twenty‐eight measurements of 99mTc‐DTPA GFR were compared with simultaneous measurements of serum cystatin C and Cr. Linear regression analysis, Pearson correlation coefficients and analysis of variance (anova) were used to determine the relationship between creatinine, cystatin C and GFR. The correlation coefficients (R2) for the relationship of 1/Cr to DTPA‐GFR and for 1/cystatin C to DTPA‐GFR were 0.63 and 0.58, respectively. There was no significant difference between serum cystatin C and serum creatinine as markers of GFR. Serum cystatin C, which costs more to measure than serum creatinine, offers no advantage in monitoring the renal function of pediatric renal transplant recipients. |
| doi_str_mv | 10.1034/j.1399-3046.2002.02012.x |
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Nineteen pediatric renal transplant recipients, 15 male and 4 female, ranging in age from 8.35 yr to 19.06 yr (median 13.52 yr), were enrolled in the study over an 18‐month period. Twenty‐eight measurements of 99mTc‐DTPA GFR were compared with simultaneous measurements of serum cystatin C and Cr. Linear regression analysis, Pearson correlation coefficients and analysis of variance (anova) were used to determine the relationship between creatinine, cystatin C and GFR. The correlation coefficients (R2) for the relationship of 1/Cr to DTPA‐GFR and for 1/cystatin C to DTPA‐GFR were 0.63 and 0.58, respectively. There was no significant difference between serum cystatin C and serum creatinine as markers of GFR. Serum cystatin C, which costs more to measure than serum creatinine, offers no advantage in monitoring the renal function of pediatric renal transplant recipients.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1034/j.1399-3046.2002.02012.x</identifier><identifier>PMID: 12390425</identifier><language>eng</language><publisher>Copenhagen, Denmark: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Child ; creatinine ; Creatinine - blood ; Cystatin C ; Cystatins - blood ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Function Tests ; kidney transplantation ; Kidney Transplantation - physiology ; Male ; Medical sciences ; Pilot Projects ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; Tropical medicine</subject><ispartof>Pediatric transplantation, 2002-10, Vol.6 (5), p.392-395</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4322-630fc10ea36d78a4c694ba3f773e9487568526d246ec14fbdcc9ce0f200559d3</citedby><cites>FETCH-LOGICAL-c4322-630fc10ea36d78a4c694ba3f773e9487568526d246ec14fbdcc9ce0f200559d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1399-3046.2002.02012.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-3046.2002.02012.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13988557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12390425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krieser, David</creatorcontrib><creatorcontrib>Rosenberg, Andrew R.</creatorcontrib><creatorcontrib>Kainer, Gad</creatorcontrib><creatorcontrib>Daya Naidoo</creatorcontrib><title>The relationship between serum creatinine, serum cystatin C and glomerular filtration rate in pediatric renal transplant recipients: A pilot study</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>: Serum cystatin C more accurately reflects glomerular filtration rate (GFR) in pediatric renal transplant recipients than serum creatinine. Nineteen pediatric renal transplant recipients, 15 male and 4 female, ranging in age from 8.35 yr to 19.06 yr (median 13.52 yr), were enrolled in the study over an 18‐month period. Twenty‐eight measurements of 99mTc‐DTPA GFR were compared with simultaneous measurements of serum cystatin C and Cr. Linear regression analysis, Pearson correlation coefficients and analysis of variance (anova) were used to determine the relationship between creatinine, cystatin C and GFR. The correlation coefficients (R2) for the relationship of 1/Cr to DTPA‐GFR and for 1/cystatin C to DTPA‐GFR were 0.63 and 0.58, respectively. There was no significant difference between serum cystatin C and serum creatinine as markers of GFR. Serum cystatin C, which costs more to measure than serum creatinine, offers no advantage in monitoring the renal function of pediatric renal transplant recipients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>creatinine</subject><subject>Creatinine - blood</subject><subject>Cystatin C</subject><subject>Cystatins - blood</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney Function Tests</subject><subject>kidney transplantation</subject><subject>Kidney Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pilot Projects</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>Tropical medicine</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdtuEzEQhi0EoiXwCsg3cMUuPu0JcVOFJkWqCoqicmk53lnq4D3U9qrJa_DE9SahveVqrH--3zP6ByFMSUoJF5-3KeVVlXAi8pQRwlLCCGXp7gU6f2q8PLyLhFPBztAb77eE0FyU4jU6o4xXRLDsHP1d3wF2YFUwfefvzIA3EB4AOuzBjS3WDmKrMx18-qfsfZgkPMeqq_Fv27dRt8rhxtjgDh_hWABHZoDaqOCMjjM6ZXHsd36wqgtR0GYw0AX_BV_gwdg-YB_Gev8WvWqU9fDuVGdovbhcz6-S6x_L7_OL60QLzliSc9JoSkDxvC5KJXReiY3iTVFwqERZZHmZsbxmIgdNRbOpta40kCbmlWVVzWfo4_HbwfX3I_ggW-M12Lgc9KOXBaNVzK6MYHkEteu9d9DIwZlWub2kRE7nkFs5pS6n1OV0Dnk4h9xF6_vTjHHTQv1sPOUfgQ8nQHmtbBPj0cY_c7wqyywrIvf1yD0YC_v_XkD-vFyv4rAZSo524wPsnuzK_ZF5wYtM_rpZysW31e3qZnkrF_wR7lC4KA</recordid><startdate>200210</startdate><enddate>200210</enddate><creator>Krieser, David</creator><creator>Rosenberg, Andrew R.</creator><creator>Kainer, Gad</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200210</creationdate><title>The relationship between serum creatinine, serum cystatin C and glomerular filtration rate in pediatric renal transplant recipients: A pilot study</title><author>Krieser, David ; Rosenberg, Andrew R. ; Kainer, Gad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4322-630fc10ea36d78a4c694ba3f773e9487568526d246ec14fbdcc9ce0f200559d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>creatinine</topic><topic>Creatinine - blood</topic><topic>Cystatin C</topic><topic>Cystatins - blood</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney Function Tests</topic><topic>kidney transplantation</topic><topic>Kidney Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pilot Projects</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krieser, David</creatorcontrib><creatorcontrib>Rosenberg, Andrew R.</creatorcontrib><creatorcontrib>Kainer, Gad</creatorcontrib><creatorcontrib>Daya Naidoo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krieser, David</au><au>Rosenberg, Andrew R.</au><au>Kainer, Gad</au><aucorp>Daya Naidoo</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between serum creatinine, serum cystatin C and glomerular filtration rate in pediatric renal transplant recipients: A pilot study</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2002-10</date><risdate>2002</risdate><volume>6</volume><issue>5</issue><spage>392</spage><epage>395</epage><pages>392-395</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>: Serum cystatin C more accurately reflects glomerular filtration rate (GFR) in pediatric renal transplant recipients than serum creatinine. Nineteen pediatric renal transplant recipients, 15 male and 4 female, ranging in age from 8.35 yr to 19.06 yr (median 13.52 yr), were enrolled in the study over an 18‐month period. Twenty‐eight measurements of 99mTc‐DTPA GFR were compared with simultaneous measurements of serum cystatin C and Cr. Linear regression analysis, Pearson correlation coefficients and analysis of variance (anova) were used to determine the relationship between creatinine, cystatin C and GFR. The correlation coefficients (R2) for the relationship of 1/Cr to DTPA‐GFR and for 1/cystatin C to DTPA‐GFR were 0.63 and 0.58, respectively. There was no significant difference between serum cystatin C and serum creatinine as markers of GFR. Serum cystatin C, which costs more to measure than serum creatinine, offers no advantage in monitoring the renal function of pediatric renal transplant recipients.</abstract><cop>Copenhagen, Denmark</cop><pub>Munksgaard International Publishers</pub><pmid>12390425</pmid><doi>10.1034/j.1399-3046.2002.02012.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pediatric transplantation, 2002-10, Vol.6 (5), p.392-395 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Biological and medical sciences Child creatinine Creatinine - blood Cystatin C Cystatins - blood Female Glomerular Filtration Rate Humans Kidney Function Tests kidney transplantation Kidney Transplantation - physiology Male Medical sciences Pilot Projects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Tropical medicine |
| title | The relationship between serum creatinine, serum cystatin C and glomerular filtration rate in pediatric renal transplant recipients: A pilot study |
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