The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells

The relationship is investigated between mitochondrial membrane potential (Delta Psi(M)), respiration and cytochrome c (cyt c) release in single neural bcl-2 transfected cells (GT1-7bcl-2) or GT1-7puro cells during apoptosis induced by staurosporine (STS). Bcl-2 inhibited the mitochondrial release o...

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Veröffentlicht in:	Cell death and differentiation 2001-10, Vol.8 (10), p.995-1003
Hauptverfasser:	Rego, A C, Vesce, S, Nicholls, D G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bioenergetics Cell death Cell Line Cell Respiration - drug effects Cytochrome Cytochrome c Group - metabolism Enzyme Inhibitors - pharmacology Kinases Kinetics Membrane Potentials Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology Neurons - cytology Neurons - drug effects Neurons - metabolism Oligomycins - pharmacology Permeability Protein Kinase Inhibitors Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Proton-Translocating ATPases - metabolism Respiration Retention Staurosporine - pharmacology Transfection
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