Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis

Gelatinase A (MMP‐2), a matrix metalloproteinase (MMP) involved in tumor invasion and angiogenesis, is secreted as an inactive zymogen (proMMP‐2) and activated by proteolytic cleavage. Here we report that polymorphonuclear neutrophil (PMN)‐derived elastase, cathepsin G, and proteinase‐3 activate pro...

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Veröffentlicht in:	Journal of cellular physiology 2001-11, Vol.189 (2), p.197-206
Hauptverfasser:	Shamamian, Peter, Schwartz, Jess D., Pocock, Ben J.Z., Monea, Sara, Whiting, David, Marcus, Stuart G., Mignatti, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cathepsin G Cathepsins - pharmacology Cells, Cultured Culture Media, Conditioned - pharmacology Enzyme Activation Enzyme Precursors - metabolism Gelatinases - metabolism Humans Leukocyte Elastase - pharmacology Matrix Metalloproteinases, Membrane-Associated Metalloendopeptidases - metabolism Metalloendopeptidases - physiology Models, Biological Myeloblastin Neoplasm Invasiveness Neovascularization, Pathologic Neutrophils - enzymology Neutrophils - physiology Serine Endopeptidases - pharmacology Tumor Cells, Cultured
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