Expression of P21(WAF1/CIP1/SID1) cyclin-dependent kinase inhibitor in hematopoietic progenitor cells

P21(Waf1/Cip1/Sid1) is a critical component of biomolecular pathways leading to the G(1) arrest evoked in response to DNA damage, growth arrest signals and differentiation commitment. It belongs to the Cip/Kip class of cyclin-dependent kinase inhibitors and is at least partly regulated by p53. P21(W...

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Veröffentlicht in:	Gene 2001-08, Vol.273 (2), p.173-180
Hauptverfasser:	Campanini, F, Santucci, M A, Brusa, G, Pattacini, L, Arpinati, M, Rondelli, D, Gamberi, B, Barbieri, E, Babini, L, Tura, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle - genetics Cell Cycle - radiation effects Cell Division - genetics Cell Division - radiation effects Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics DNA Repair Gene Expression Gene Expression Regulation, Neoplastic - radiation effects Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - radiation effects Humans Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Tumor Cells, Cultured
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