Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-β in human umbilical vein endothelial cells

Transforming growth factor‐β (TGF‐β) plays a crucial role in vascular development and homeostasis by regulating many transcriptional targets. Activin receptor‐like kinase 5 (ALK‐5) is a TGF‐β type I receptor expressed in various TGF‐β‐responsive cells. In contrast, ALK‐1 functions as a TGF‐β type I...

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Veröffentlicht in:	Journal of cellular physiology 2002-12, Vol.193 (3), p.299-318
Hauptverfasser:	Ota, Tatsuru, Fujii, Makiko, Sugizaki, Takashi, Ishii, Masami, Miyazawa, Keiji, Aburatani, Hiroyuki, Miyazono, Kohei
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type I - classification Activin Receptors, Type I - genetics Activin Receptors, Type I - physiology Activin Receptors, Type II Cells, Cultured Down-Regulation Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Gene Expression Profiling Humans Models, Biological Mutation Oligonucleotide Array Sequence Analysis Protein-Serine-Threonine Kinases Receptors, Transforming Growth Factor beta - classification Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - physiology RNA, Messenger - analysis Transcription, Genetic Transforming Growth Factor beta - physiology Umbilical Veins - cytology Up-Regulation
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