Correlation Between the Loss of the Chaperone-like Activity and the Oxidation, Isomerization and Racemization of Gamma-irradiated Alpha-crystallin

Alpha-crystallin possesses a molecular chaperone-like activity that prevents proteins from aggregating; however, the mechanism of this activity is not well known. Here we have taken gamma-irradiated alpha-crystallin and studied the relationship between the decrease in chaperone-like activity and the...

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Veröffentlicht in:	Photochemistry and photobiology 2001-09, Vol.74 (3), p.477-482
Hauptverfasser:	Fujii, N., Hiroki, K., Matsumoto, S., Masuda, K., Inoue, M., Tanaka, Y., Awakura, M., Akaboshi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - chemistry Aspartic Acid - radiation effects Cattle Crystallins - chemistry Crystallins - radiation effects Gamma Rays - adverse effects In Vitro Techniques Isomerism Molecular Chaperones - chemistry Molecular Chaperones - radiation effects Oxidation-Reduction Photochemistry PHOTOSENSORY BIOLOGY Protein Structure, Secondary - radiation effects Protein Structure, Tertiary - radiation effects Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stereoisomerism
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