Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients
Periostin protein shares structural and sequence homology with fasciclin I, which is an insect adhesion molecule. Periostin has a typical signal peptide at the N-terminal end suggesting it is a secreted protein. Recently, we developed a novel sandwich chemiluminescence assay to determine serum conce...
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| Veröffentlicht in: | Cancer letters 2001-10, Vol.172 (1), p.37-42 |
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| container_title | Cancer letters |
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| creator | Sasaki, Hidefumi Auclair, Daniel Kaji, Masahiro Fukai, Ichiro Kiriyama, Masanobu Yamakawa, Yosuke Fujii, Yoshitaka Chen, Lan Bo |
| description | Periostin protein shares structural and sequence homology with fasciclin I, which is an insect adhesion molecule. Periostin has a typical signal peptide at the N-terminal end suggesting it is a secreted protein. Recently, we developed a novel sandwich chemiluminescence assay to determine serum concentrations of periostin. We investigated the serum periostin level in thymoma patients, and attempted to determine the correlation between serum periostin level and clinicopathological factors of thymoma patients who had undergone surgery between January 1994 and July 1996. Serum periostin levels were not significantly different between the thymoma patients (1264.4±122.9 ng/ml) and the normal control (962.0±118.6 ng/ml) (
P=0.0877). There was no relationship between serum periostin level and age, gender or pathological subtype. However the serum periostin level of stage IV patients (1497.0±285.8 ng/ml) was significantly higher than normal control (
P=0.0460). These data suggest that serum periostin level may indicate tumor invasion and progression of thymoma. |
| doi_str_mv | 10.1016/S0304-3835(01)00633-4 |
| format | Article |
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P=0.0877). There was no relationship between serum periostin level and age, gender or pathological subtype. However the serum periostin level of stage IV patients (1497.0±285.8 ng/ml) was significantly higher than normal control (
P=0.0460). These data suggest that serum periostin level may indicate tumor invasion and progression of thymoma.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(01)00633-4</identifier><identifier>PMID: 11595127</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age Factors ; Biological and medical sciences ; Cell Adhesion ; Cell Adhesion Molecules - blood ; Chemiluminescence ; Disease Progression ; Humans ; Invasive thymoma ; Luminescent Measurements ; Medical sciences ; Middle Aged ; Periostin ; Pneumology ; Protein Structure, Tertiary ; Sex Factors ; Thymoma ; Thymoma - blood ; Thymoma - diagnosis ; Thymoma - surgery ; Thymus Neoplasms - blood ; Thymus Neoplasms - diagnosis ; Thymus Neoplasms - surgery ; Tumors of the respiratory system and mediastinum ; Up-Regulation</subject><ispartof>Cancer letters, 2001-10, Vol.172 (1), p.37-42</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-8d65e99dd47e29d1fd3e7e2222faaf024d9338c70fff428d26dd4b31e6121b593</citedby><cites>FETCH-LOGICAL-c508t-8d65e99dd47e29d1fd3e7e2222faaf024d9338c70fff428d26dd4b31e6121b593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383501006334$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1137854$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11595127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasaki, Hidefumi</creatorcontrib><creatorcontrib>Auclair, Daniel</creatorcontrib><creatorcontrib>Kaji, Masahiro</creatorcontrib><creatorcontrib>Fukai, Ichiro</creatorcontrib><creatorcontrib>Kiriyama, Masanobu</creatorcontrib><creatorcontrib>Yamakawa, Yosuke</creatorcontrib><creatorcontrib>Fujii, Yoshitaka</creatorcontrib><creatorcontrib>Chen, Lan Bo</creatorcontrib><title>Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Periostin protein shares structural and sequence homology with fasciclin I, which is an insect adhesion molecule. Periostin has a typical signal peptide at the N-terminal end suggesting it is a secreted protein. Recently, we developed a novel sandwich chemiluminescence assay to determine serum concentrations of periostin. We investigated the serum periostin level in thymoma patients, and attempted to determine the correlation between serum periostin level and clinicopathological factors of thymoma patients who had undergone surgery between January 1994 and July 1996. Serum periostin levels were not significantly different between the thymoma patients (1264.4±122.9 ng/ml) and the normal control (962.0±118.6 ng/ml) (
P=0.0877). There was no relationship between serum periostin level and age, gender or pathological subtype. However the serum periostin level of stage IV patients (1497.0±285.8 ng/ml) was significantly higher than normal control (
P=0.0460). These data suggest that serum periostin level may indicate tumor invasion and progression of thymoma.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Chemiluminescence</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Invasive thymoma</subject><subject>Luminescent Measurements</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Periostin</subject><subject>Pneumology</subject><subject>Protein Structure, Tertiary</subject><subject>Sex Factors</subject><subject>Thymoma</subject><subject>Thymoma - blood</subject><subject>Thymoma - diagnosis</subject><subject>Thymoma - surgery</subject><subject>Thymus Neoplasms - blood</subject><subject>Thymus Neoplasms - diagnosis</subject><subject>Thymus Neoplasms - surgery</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Up-Regulation</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1UBFvgJ1D5UFVFIuCJ43ycULUCioTEgfZsOfaYNUrixU5W4t_jsKvCrXPxSPPM69FDyCmwC2BQXj4yzoqM11z8ZHDGWMl5VuyRBdRVnlVNzb6QxT_kkHyN8ZkxJopKHJBDANEIyKsFaR8xTD3tcIMd9ZaOK6RrDM7H0Q3nVNGV733nnyacp2qgboioR6qx66gyK4zODzQhqKcOz9M4Rbz2vld0rUaHwxiPyb5VXcST3XtE_t5c_1n-zu4fbu-Wv-4zLVg9ZrUpBTaNMUWFeWPAGo6pS2WVsiwvTMN5rStmrS3y2uRlQlsOWEIOrWj4EfmxzV0H_zJhHGXv4nynGtBPUVY5NAC8SKDYgjr4GANauQ6uV-FVApOzXPkuV87mJAP5LlfOe992H0xtj-Zja2czAd93gIpadTaoQbv4ieNVLeacqy2GycbGYZBRJ1MajQvJrTTe_eeSN1vgli4</recordid><startdate>20011022</startdate><enddate>20011022</enddate><creator>Sasaki, Hidefumi</creator><creator>Auclair, Daniel</creator><creator>Kaji, Masahiro</creator><creator>Fukai, Ichiro</creator><creator>Kiriyama, Masanobu</creator><creator>Yamakawa, Yosuke</creator><creator>Fujii, Yoshitaka</creator><creator>Chen, Lan Bo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011022</creationdate><title>Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients</title><author>Sasaki, Hidefumi ; Auclair, Daniel ; Kaji, Masahiro ; Fukai, Ichiro ; Kiriyama, Masanobu ; Yamakawa, Yosuke ; Fujii, Yoshitaka ; Chen, Lan Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-8d65e99dd47e29d1fd3e7e2222faaf024d9338c70fff428d26dd4b31e6121b593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Chemiluminescence</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Invasive thymoma</topic><topic>Luminescent Measurements</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Periostin</topic><topic>Pneumology</topic><topic>Protein Structure, Tertiary</topic><topic>Sex Factors</topic><topic>Thymoma</topic><topic>Thymoma - blood</topic><topic>Thymoma - diagnosis</topic><topic>Thymoma - surgery</topic><topic>Thymus Neoplasms - blood</topic><topic>Thymus Neoplasms - diagnosis</topic><topic>Thymus Neoplasms - surgery</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasaki, Hidefumi</creatorcontrib><creatorcontrib>Auclair, Daniel</creatorcontrib><creatorcontrib>Kaji, Masahiro</creatorcontrib><creatorcontrib>Fukai, Ichiro</creatorcontrib><creatorcontrib>Kiriyama, Masanobu</creatorcontrib><creatorcontrib>Yamakawa, Yosuke</creatorcontrib><creatorcontrib>Fujii, Yoshitaka</creatorcontrib><creatorcontrib>Chen, Lan Bo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasaki, Hidefumi</au><au>Auclair, Daniel</au><au>Kaji, Masahiro</au><au>Fukai, Ichiro</au><au>Kiriyama, Masanobu</au><au>Yamakawa, Yosuke</au><au>Fujii, Yoshitaka</au><au>Chen, Lan Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2001-10-22</date><risdate>2001</risdate><volume>172</volume><issue>1</issue><spage>37</spage><epage>42</epage><pages>37-42</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Periostin protein shares structural and sequence homology with fasciclin I, which is an insect adhesion molecule. Periostin has a typical signal peptide at the N-terminal end suggesting it is a secreted protein. Recently, we developed a novel sandwich chemiluminescence assay to determine serum concentrations of periostin. We investigated the serum periostin level in thymoma patients, and attempted to determine the correlation between serum periostin level and clinicopathological factors of thymoma patients who had undergone surgery between January 1994 and July 1996. Serum periostin levels were not significantly different between the thymoma patients (1264.4±122.9 ng/ml) and the normal control (962.0±118.6 ng/ml) (
P=0.0877). There was no relationship between serum periostin level and age, gender or pathological subtype. However the serum periostin level of stage IV patients (1497.0±285.8 ng/ml) was significantly higher than normal control (
P=0.0460). These data suggest that serum periostin level may indicate tumor invasion and progression of thymoma.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11595127</pmid><doi>10.1016/S0304-3835(01)00633-4</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Factors Biological and medical sciences Cell Adhesion Cell Adhesion Molecules - blood Chemiluminescence Disease Progression Humans Invasive thymoma Luminescent Measurements Medical sciences Middle Aged Periostin Pneumology Protein Structure, Tertiary Sex Factors Thymoma Thymoma - blood Thymoma - diagnosis Thymoma - surgery Thymus Neoplasms - blood Thymus Neoplasms - diagnosis Thymus Neoplasms - surgery Tumors of the respiratory system and mediastinum Up-Regulation |
| title | Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients |
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